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- W2023667741 abstract "Summary Cancer cells that originate from epithelial tissues typically lose epithelial specific cell–cell junctions, but these transformed cells are not devoid of cell–cell adhesion proteins. Using hepatocyte-growth-factor-treated MDCK cells that underwent a complete epithelial-to-mesenchymal transition, we analyzed cell–cell adhesion between these highly invasive transformed epithelial cells in a three-dimensional (3D) collagen matrix. In a 3D matrix, these transformed cells formed elongated multicellular chains, and migrated faster and more persistently than single cells in isolation. In addition, the cell clusters were enriched with stress-fiber-like actin bundles that provided contractile forces. N-cadherin-knockdown cells failed to form cell–cell junctions or migrate, and the expression of the N-cadherin cytoplasmic or extracellular domain partially rescued the knockdown phenotype. By contrast, the expression of N-cadherin–α-catenin chimera rescued the knockdown phenotype, but individual cells within the cell clusters were less mobile. Together, our findings suggest that a dynamic N-cadherin and actin linkage is required for efficient 3D collective migration." @default.
- W2023667741 created "2016-06-24" @default.
- W2023667741 creator A5051290510 @default.
- W2023667741 creator A5073111678 @default.
- W2023667741 date "2012-08-01" @default.
- W2023667741 modified "2023-10-02" @default.
- W2023667741 title "N-cadherin-mediated cell–cell adhesion promotes cell migration in a three-dimensional matrix" @default.
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- W2023667741 doi "https://doi.org/10.1242/jcs.103861" @default.
- W2023667741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3445327" @default.
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