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- W2023667812 endingPage "30" @default.
- W2023667812 startingPage "8" @default.
- W2023667812 abstract "Estrogen is a fundamental regulator of the metabolic system of the female brain and body. Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial function to generate ATP. In the body, estrogen protects against adiposity, insulin resistance, and type II diabetes, and regulates energy intake and expenditure. During menopause, decline in circulating estrogen is coincident with decline in brain bioenergetics and shift towards a metabolically compromised phenotype. Compensatory bioenergetic adaptations, or lack thereof, to estrogen loss could determine risk of late-onset Alzheimer's disease. Estrogen coordinates brain and body metabolism, such that peripheral metabolic state can indicate bioenergetic status of the brain. By generating biomarker profiles that encompass peripheral metabolic changes occurring with menopause, individual risk profiles for decreased brain bioenergetics and cognitive decline can be created. Biomarker profiles could identify women at risk while also serving as indicators of efficacy of hormone therapy or other preventative interventions." @default.
- W2023667812 created "2016-06-24" @default.
- W2023667812 creator A5000018634 @default.
- W2023667812 creator A5005920250 @default.
- W2023667812 creator A5007974895 @default.
- W2023667812 date "2014-01-01" @default.
- W2023667812 modified "2023-10-17" @default.
- W2023667812 title "Estrogen: A master regulator of bioenergetic systems in the brain and body" @default.
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