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• W2023671509 abstract "Abstract These studies focus on one fundamental aspect of steroid hormone receptor-containing neurons, their connectivity. We seek to determine exactly how these neurons fit into neuroendocrinologically or behaviorally relevant neural circuits. To examine precisely the efferent projections of steroid hormone receptor-containing neurons, we combined steroid hormone autoradiography with retrograde neuroanatomlcal tracing using fluorescent dyes. By means of standard stereotaxic procedures, fluorescent dyes or microspheres are injected Into particular limited regions of the brains of deeply anesthetized rodents. After several days or weeks to allow retrograde transport of the tracer to fill the neuronal somas, a physiological dose of a highly radioactive steroid hormone (100–400μCi/100 g body wt) Is administered. Animals are sacrificed after 1–2 h, when nuclear retention of the steroid hormone Is high and when circulating levels of hormone have begun to fall. The hormone status of the animal must be such that the sources of endogenous circulating steroid hormones are removed by gonadectomy and/or adrenalectomy so that circulating endogenous steroid hormones will not compete with the labeled hormones for the finite population of receptors. Since hormonal status is now understood to have profound effects on the abundance of gonadal steroid hormone receptors, each type of receptor being differently regulated, an optimal endocrine condition must be selected for each experiment. Animals are perfused, the brains cryoprotected, and autoradiograms prepared under safelight conditions by picking up cryostat-cut sections on emulsion-coated slides. After autoradiographic exposure of 4–12 months, the autoradiograms are developed, and the slides are examined with a light microscope for the presence of steroid hormone-concentrating neurons that send their efferent projections to particular anatomical sites. It is possible to generalize from the substantial number of experiments carried out with this method. All types of gonadal steroid hormone-concentrating neurons, that Is, estrogen-, androgen-, and progestin-concentrating neurons, have axons that project long distances from regions that contain large numbers of the hormone-concentrating neurons to regions that contain relatively few. These long-projecting steroid hormone-concentrating neurons are found predominantly in the preoptic area, bed nucleus of the stria terminalis, and hypothalamus and are relatively rare or weak in the amygdala. These long-projecting steroid hormone-concentrating neurons may be an important route over which integrated, steroid hormone-modulated Information is conveyed to the effector portions of neural circuits." @default.
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• W2023671509 date "1992-08-01" @default.
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• W2023671509 title "Axonal projections of gonadal steroid receptor-containing neurons" @default.
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• W2023671509 doi "https://doi.org/10.1016/1058-6741(92)90016-q" @default.
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