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- W2023671616 endingPage "175" @default.
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- W2023671616 abstract "In aqueous media of low ionic strength (Na+ = 6 × 10−3M) the alkaloid cyclobuxine, a steroidal diamine, exerts a profound effect on the stability of helical polynucleotides (DNA, S-RNA and dAT:dAT). This effect is biphasic in the sense that at low concentrations of the agent (≤ 10−4M) there is stabilization of the native, while at higher concentrations (≥5 × 10−4M) there is stabilization of the denatured conformation. In a medium containing 51% methanol only the labilizing interaction persists while at high ionic strength both types of interaction are eliminated. These effects of cyclobuxine are restricted to the reversible order—disorder transition and do not extend to strand separation or re-combination. Cyclobuxine affects the absorption spectrum of DNA and other polynucleotides by producing a generalized hyperchromicity centered at 270 mμ. For low concentrations of the agent the magnitude of this increased absorption falls in the order native DNA > denatured DNA ~ S-RNA > polyribonucleotides » nucleotides." @default.
- W2023671616 created "2016-06-24" @default.
- W2023671616 creator A5041879434 @default.
- W2023671616 creator A5091260072 @default.
- W2023671616 date "1964-10-01" @default.
- W2023671616 modified "2023-09-27" @default.
- W2023671616 title "Nucleic acid interactions. V. Effects of cyclobuxine" @default.
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- W2023671616 doi "https://doi.org/10.1016/s0022-2836(64)80035-8" @default.
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