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• W2023671679 abstract "To research a new non-peptidyl inhibitor of beta-site amyloid precursor protein cleaving enzyme 1, we focused on the curcumin framework, two phenolic groups combined with an sp2 carbon spacer for low-molecular and high lipophilicity. The structure–activity relationship study of curcumin derivatives is described. Our results indicate that phenolic hydroxy groups and an alkenyl spacer are important structural factors for the inhibition of beta-site amyloid precursor protein cleaving enzyme 1 and, furthermore, non-competitive inhibition of enzyme activity is anticipated from an inhibitory kinetics experiment and docking simulation." @default.
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• W2023671679 date "2014-01-01" @default.
• W2023671679 modified "2023-10-02" @default.
• W2023671679 title "Synthesis and evaluation of curcumin derivatives toward an inhibitor of beta-site amyloid precursor protein cleaving enzyme 1" @default.
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• W2023671679 doi "https://doi.org/10.1016/j.bmcl.2013.11.039" @default.
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• W2023671679 hasPublicationYear "2014" @default.
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