FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023672273> ?p ?o ?g. }

• W2023672273 endingPage "2208" @default.
• W2023672273 startingPage "2200" @default.
• W2023672273 abstract "Heterotrimeric GTP-binding (G) proteins transduce hormone-induced signals to their effector enzymes, which include several phospholipases. In particular, the G o /G i and G q protein families have been shown to couple signaling to phospholipase A 2 (PLA 2 ), phospholipase C, and phospholipase D, while the G 12 /G 13 family has been linked to the activation of small GTPases of the Rho family, and hence, to phospholipase D activation. Here, we demonstrate that in CHO cells, the G 12 /G 13 family is also able to activate cPLA 2 α, through the activation of RhoA and, subsequently, ERK1/2. Hormone-induced arachidonic acid release increased as a consequence of Gα 13 overexpression, and was inhibited through inhibition of Gα 13 signaling. The Gα 13 -mediated cPLA 2 α activation was inhibited by pharmacological blockade of ERK1/2 with either U0126 or PD98059, and by RhoA inactivation with C3 toxin or a dominant-negative RhoA (N19RhoA), and was stimulated by the serine–threonine phosphatase inhibitor calyculin A. Our data thus identify a pathway of cPLA 2 α regulation that is initiated by thrombin and purinergic receptor activation, and that signals through Gα 13 , RhoA and ERK1/2, with the involvement of a calyculin-sensitive phosphatase." @default.
• W2023672273 created "2016-06-24" @default.
• W2023672273 creator A5010000881 @default.
• W2023672273 creator A5020722865 @default.
• W2023672273 creator A5027586402 @default.
• W2023672273 creator A5047098934 @default.
• W2023672273 creator A5070957631 @default.
• W2023672273 creator A5071985176 @default.
• W2023672273 creator A5080244425 @default.
• W2023672273 date "2006-12-01" @default.
• W2023672273 modified "2023-09-25" @default.
• W2023672273 title "Gα13 mediates activation of the cytosolic phospholipase A2α through fine regulation of ERK phosphorylation" @default.
• W2023672273 cites W1486847030 @default.
• W2023672273 cites W1517746500 @default.
• W2023672273 cites W1517887854 @default.
• W2023672273 cites W1596536567 @default.
• W2023672273 cites W1773327886 @default.
• W2023672273 cites W180059560 @default.
• W2023672273 cites W1971915141 @default.
• W2023672273 cites W1972760976 @default.
• W2023672273 cites W1977929190 @default.
• W2023672273 cites W1989683016 @default.
• W2023672273 cites W1995996832 @default.
• W2023672273 cites W1998529477 @default.
• W2023672273 cites W2001534326 @default.
• W2023672273 cites W2005593816 @default.
• W2023672273 cites W2012397093 @default.
• W2023672273 cites W2015176049 @default.
• W2023672273 cites W2022037486 @default.
• W2023672273 cites W2022723700 @default.
• W2023672273 cites W2024663313 @default.
• W2023672273 cites W2029253559 @default.
• W2023672273 cites W2030625703 @default.
• W2023672273 cites W2031557719 @default.
• W2023672273 cites W2031683755 @default.
• W2023672273 cites W2035936653 @default.
• W2023672273 cites W2038106230 @default.
• W2023672273 cites W2038833293 @default.
• W2023672273 cites W2041658762 @default.
• W2023672273 cites W2042921323 @default.
• W2023672273 cites W2051958752 @default.
• W2023672273 cites W2058284416 @default.
• W2023672273 cites W2063250965 @default.
• W2023672273 cites W2064483656 @default.
• W2023672273 cites W2068323006 @default.
• W2023672273 cites W2068990208 @default.
• W2023672273 cites W2071881246 @default.
• W2023672273 cites W2072519737 @default.
• W2023672273 cites W2073079404 @default.
• W2023672273 cites W2077537799 @default.
• W2023672273 cites W2080953730 @default.
• W2023672273 cites W2081847534 @default.
• W2023672273 cites W2088927230 @default.
• W2023672273 cites W2091061305 @default.
• W2023672273 cites W2093753608 @default.
• W2023672273 cites W2106263242 @default.
• W2023672273 cites W2127771541 @default.
• W2023672273 cites W2130027917 @default.
• W2023672273 cites W2135587043 @default.
• W2023672273 cites W2144554951 @default.
• W2023672273 cites W2146388445 @default.
• W2023672273 cites W2153283433 @default.
• W2023672273 cites W2153539273 @default.
• W2023672273 cites W2153608004 @default.
• W2023672273 cites W2155511306 @default.
• W2023672273 cites W2169316199 @default.
• W2023672273 cites W2170205898 @default.
• W2023672273 cites W2336120084 @default.
• W2023672273 cites W4254797493 @default.
• W2023672273 doi "https://doi.org/10.1016/j.cellsig.2006.05.003" @default.
• W2023672273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16806823" @default.
• W2023672273 hasPublicationYear "2006" @default.
• W2023672273 type Work @default.
• W2023672273 sameAs 2023672273 @default.
• W2023672273 citedByCount "20" @default.
• W2023672273 countsByYear W20236722732012 @default.
• W2023672273 countsByYear W20236722732013 @default.
• W2023672273 countsByYear W20236722732014 @default.
• W2023672273 countsByYear W20236722732016 @default.
• W2023672273 countsByYear W20236722732018 @default.
• W2023672273 countsByYear W20236722732020 @default.
• W2023672273 countsByYear W20236722732021 @default.
• W2023672273 countsByYear W20236722732022 @default.
• W2023672273 crossrefType "journal-article" @default.
• W2023672273 hasAuthorship W2023672273A5010000881 @default.
• W2023672273 hasAuthorship W2023672273A5020722865 @default.
• W2023672273 hasAuthorship W2023672273A5027586402 @default.
• W2023672273 hasAuthorship W2023672273A5047098934 @default.
• W2023672273 hasAuthorship W2023672273A5070957631 @default.
• W2023672273 hasAuthorship W2023672273A5071985176 @default.
• W2023672273 hasAuthorship W2023672273A5080244425 @default.
• W2023672273 hasConcept C11960822 @default.
• W2023672273 hasConcept C12927208 @default.
• W2023672273 hasConcept C139407321 @default.
• W2023672273 hasConcept C178666793 @default.
• W2023672273 hasConcept C181199279 @default.
• W2023672273 hasConcept C207332259 @default.
• W2023672273 hasConcept C2777093181 @default.

• next