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- W2023673932 abstract "In parkinsonian 6-hydroxydopamine (6-OHDA)-lesioned animals the firing discharge of the globus pallidus (GP) and the substantia nigra reticulata (SNr) are in phase with urethane-induced slow wave cortex activity (SWA). The origin of this pathological synergy, hallmark of dopamine (DA) deficiency, is debated. In order to understand the role of SN pars compacta (SNc) signaling, we performed the electrocorticogram (ECoG) and single unit recordings from GP, SNr and subthalamus (STN), before and after the injection of tetrodotoxin (TTX) into the medial forebrain bundle (MFB). This procedure led to a dramatic reduction of the DA content in the striatum and promoted reversible contra-lateral akinesia. The TTX-mediated inactivation of MFB induced a fast developing coherence between cortex/GP and cortex/SNr and a significant increase of the cortex/STN synchronization. Interestingly, the long term ECoG/GP synchronization detectable in the 6-OHDA lesioned animals did not differ from the short term one induced controlaterally by the TTX block of MFB in the normal hemisphere. Intra-GP iontophoretic delivery of the D2 receptor antagonist haloperidol or the GABA A receptor antagonist bicuculline caused a short term induction of cortex/GP synchronization. Strikingly, STN inactivation by local muscimol reversed the TTX-mediated coherence between cortex and GP. Our data show that an abnormal and diffuse cortical/basal ganglia (BG) synchronization can be reproduced in absence of SNc neuronal loss and cytoarchitectonic alteration of the striatum. In addition, our results, difficult to reconcile with ex abrupto alterations of intra-striatal plasticity, seem compatible with acute changes of the functional interplay between cortex and the STN-GP pathway." @default.
- W2023673932 created "2016-06-24" @default.
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- W2023673932 date "2012-10-01" @default.
- W2023673932 modified "2023-10-18" @default.
- W2023673932 title "P3. Pathological synchronization of the rat basal ganglia following the functional blockade of the nigro-striatal pathway" @default.
- W2023673932 doi "https://doi.org/10.1016/j.clinph.2012.03.053" @default.
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