FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023676206> ?p ?o ?g. }

• W2023676206 endingPage "164" @default.
• W2023676206 startingPage "156" @default.
• W2023676206 abstract "The cardiomyocyte phenotypic switch from a proliferative to terminally differentiated state impacts normal heart development and pathologic myocardial remodeling, yet the signaling mechanisms that regulate this vital process are incompletely understood. Studies from our lab and others indicate that focal adhesion kinase (FAK) is a critical regulator of cardiac growth and remodeling and we found that expression of the endogenous FAK inhibitor, FAK-related non kinase (FRNK) coincided with postnatal cardiomyocyte arrest. Mis-expression of FRNK in the embryonic heart led to pre-term lethality associated with reduced cardiomyocyte proliferation and led us to speculate that the postnatal FRNK surge might be required to promote quiescence in this growth promoting environment. Herein, we provide strong evidence that endogenous FRNK contributes to post-mitotic arrest. Depletion of FRNK promoted DNA synthesis in post-natal day (P) 10 hearts accompanied by a transient increase in DNA content and multi-nucleation by P14, indicative of DNA replication without cell division. Interestingly, a reduction in tri- and tetra-nucleated cardiomyocytes, concomitant with an increase in bi-nucleated cells by P21, indicated the possibility that FRNK-depleted cardiomyocytes underwent eventual cytokinesis. In support of this conclusion, Aurora B-labeled central spindles (a hallmark of cytokinesis) were observed in tetra-nucleated P20 FRNK(-/-) but not wt cardiomyocytes, while no evidence of apoptosis was observed. Moreover, hearts from FRNK null mice developed ventricular enlargement that persisted until young adulthood which resulted from myocyte expansion rather than myocyte hypertrophy or interstitial growth. These data indicate that endogenous FRNK serves an important role in limiting DNA synthesis and regulating the un-coupling between DNA synthesis and cytokinesis in the post-natal myocardium." @default.
• W2023676206 created "2016-06-24" @default.
• W2023676206 creator A5043257441 @default.
• W2023676206 creator A5049640251 @default.
• W2023676206 creator A5067416817 @default.
• W2023676206 date "2012-08-01" @default.
• W2023676206 modified "2023-10-14" @default.
• W2023676206 title "Germline deletion of FAK-related non-kinase delays post-natal cardiomyocyte mitotic arrest" @default.
• W2023676206 cites W1968404111 @default.
• W2023676206 cites W1969038150 @default.
• W2023676206 cites W1971443244 @default.
• W2023676206 cites W1978098714 @default.
• W2023676206 cites W1979571124 @default.
• W2023676206 cites W1995432419 @default.
• W2023676206 cites W1997121235 @default.
• W2023676206 cites W2000364201 @default.
• W2023676206 cites W2006332924 @default.
• W2023676206 cites W2012706299 @default.
• W2023676206 cites W2016380615 @default.
• W2023676206 cites W2022185139 @default.
• W2023676206 cites W2032794324 @default.
• W2023676206 cites W2037424183 @default.
• W2023676206 cites W2037988871 @default.
• W2023676206 cites W2057516068 @default.
• W2023676206 cites W2063705496 @default.
• W2023676206 cites W2096492016 @default.
• W2023676206 cites W2099997602 @default.
• W2023676206 cites W2100757571 @default.
• W2023676206 cites W2101076761 @default.
• W2023676206 cites W2103746819 @default.
• W2023676206 cites W2118221757 @default.
• W2023676206 cites W2119449391 @default.
• W2023676206 cites W2124955671 @default.
• W2023676206 cites W2134039588 @default.
• W2023676206 cites W2137540342 @default.
• W2023676206 cites W2137682947 @default.
• W2023676206 cites W2137898197 @default.
• W2023676206 cites W2150194898 @default.
• W2023676206 cites W2159286971 @default.
• W2023676206 doi "https://doi.org/10.1016/j.yjmcc.2012.04.007" @default.
• W2023676206 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3866956" @default.
• W2023676206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22555221" @default.
• W2023676206 hasPublicationYear "2012" @default.
• W2023676206 type Work @default.
• W2023676206 sameAs 2023676206 @default.
• W2023676206 citedByCount "7" @default.
• W2023676206 countsByYear W20236762062014 @default.
• W2023676206 countsByYear W20236762062017 @default.
• W2023676206 countsByYear W20236762062019 @default.
• W2023676206 crossrefType "journal-article" @default.
• W2023676206 hasAuthorship W2023676206A5043257441 @default.
• W2023676206 hasAuthorship W2023676206A5049640251 @default.
• W2023676206 hasAuthorship W2023676206A5067416817 @default.
• W2023676206 hasBestOaLocation W20236762062 @default.
• W2023676206 hasConcept C126322002 @default.
• W2023676206 hasConcept C134018914 @default.
• W2023676206 hasConcept C1491633281 @default.
• W2023676206 hasConcept C16613235 @default.
• W2023676206 hasConcept C184235292 @default.
• W2023676206 hasConcept C207200792 @default.
• W2023676206 hasConcept C45472230 @default.
• W2023676206 hasConcept C502942594 @default.
• W2023676206 hasConcept C54355233 @default.
• W2023676206 hasConcept C62112901 @default.
• W2023676206 hasConcept C71924100 @default.
• W2023676206 hasConcept C85813293 @default.
• W2023676206 hasConcept C86803240 @default.
• W2023676206 hasConcept C93304396 @default.
• W2023676206 hasConcept C95444343 @default.
• W2023676206 hasConceptScore W2023676206C126322002 @default.
• W2023676206 hasConceptScore W2023676206C134018914 @default.
• W2023676206 hasConceptScore W2023676206C1491633281 @default.
• W2023676206 hasConceptScore W2023676206C16613235 @default.
• W2023676206 hasConceptScore W2023676206C184235292 @default.
• W2023676206 hasConceptScore W2023676206C207200792 @default.
• W2023676206 hasConceptScore W2023676206C45472230 @default.
• W2023676206 hasConceptScore W2023676206C502942594 @default.
• W2023676206 hasConceptScore W2023676206C54355233 @default.
• W2023676206 hasConceptScore W2023676206C62112901 @default.
• W2023676206 hasConceptScore W2023676206C71924100 @default.
• W2023676206 hasConceptScore W2023676206C85813293 @default.
• W2023676206 hasConceptScore W2023676206C86803240 @default.
• W2023676206 hasConceptScore W2023676206C93304396 @default.
• W2023676206 hasConceptScore W2023676206C95444343 @default.
• W2023676206 hasIssue "2" @default.
• W2023676206 hasLocation W20236762061 @default.
• W2023676206 hasLocation W20236762062 @default.
• W2023676206 hasLocation W20236762063 @default.
• W2023676206 hasLocation W20236762064 @default.
• W2023676206 hasOpenAccess W2023676206 @default.
• W2023676206 hasPrimaryLocation W20236762061 @default.
• W2023676206 hasRelatedWork W1996960231 @default.
• W2023676206 hasRelatedWork W2005979670 @default.
• W2023676206 hasRelatedWork W2051583567 @default.
• W2023676206 hasRelatedWork W2228989826 @default.
• W2023676206 hasRelatedWork W2792575307 @default.
• W2023676206 hasRelatedWork W3183885323 @default.
• W2023676206 hasRelatedWork W3199204979 @default.

• next