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- W2023676537 abstract "A statistical analysis has been performed on a set of 59 published survival curves of human cell lines. Six fibroblast cell lines derived from patients free of genetic disorders and 36 tumor cell lines were used in this study. Using the linear quadratic (L-Q) model, which provides an overall adequate fitting, especially in the low dose range, we show that great variations in radiosensitivity exist among cell lines. In the low dose range (≅2 Gy), these variations cannot be explained on the mere basis of technical factors. Cell type is described as an intrinsic radiosensitivity factor, as variations of mean radiosensitivity among cell types are statistically significant at low doses. A correlation is found between the 95% tumor control dose and the mean surviving fraction at 2 Gy for a given cell type. Higher radiosensitivity is accompanied by lower tumor control dose (TCD 95 % ). This correlation suggests that the moderate radiocurability of certain tumors can be partially explained by the intrinsic radiosensitivity of relevant tumor cells and in particular by a high surviving fraction at 2 Gy." @default.
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- W2023676537 date "1981-05-01" @default.
- W2023676537 modified "2023-09-25" @default.
- W2023676537 title "Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy" @default.
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- W2023676537 doi "https://doi.org/10.1016/0360-3016(81)90377-1" @default.
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