Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023676609> ?p ?o ?g. }
- W2023676609 endingPage "740" @default.
- W2023676609 startingPage "733" @default.
- W2023676609 abstract "Scope Anti‐atherogenic features of olive oil (OO) have been attributed, in part, to minor compounds, via diverse mechanisms, although its effects on the CD 36 receptor have not been examined. We investigated the effects of minor compounds of OO (squalene ( SQ ), tyrosol ( T yr) and hydroxytyrosol ( OH ‐ T yr)), on the expression of the CD 36 receptor, as well as on monocyte/macrophage differentiation and proliferation. Methods and results U 937 monocytic cells and macrophages (obtained with 10 nM phorbol‐myristate‐acetate) were exposed to T yr, OH ‐ T yr or SQ at 0, 10, 75 and 200 μM with/without native or oxidised LDL (ox LDL ). Flow cytometry was used to achieve the expression of CD 36 in both cell types exposed to ox LDL plus antioxidants, as well as the inhibition of monocyte/macrophage differentiation after ox LDL and apoptosis. SQ caused a dose‐dependent reduction of CD 36 in the presence of native and moderate LDL in monocytes and macrophages. Phenotype‐dependent cytotoxic and antiproliferative effects were found for OH ‐ T yr ( p < 0.05), while SQ affected neither monocytes nor macrophages ( p < 0.01). Conclusion SQ does not prevent monocyte migration and activation into macrophages, but it would inhibit ox LDL uptake by macrophages, by reducing CD 36 expression. This study provides new data about the role of the components of OO in the prevention of atherosclerosis." @default.
- W2023676609 created "2016-06-24" @default.
- W2023676609 creator A5023918274 @default.
- W2023676609 creator A5036812594 @default.
- W2023676609 creator A5042190205 @default.
- W2023676609 creator A5055097306 @default.
- W2023676609 creator A5057137058 @default.
- W2023676609 creator A5061138653 @default.
- W2023676609 creator A5080829001 @default.
- W2023676609 date "2012-05-01" @default.
- W2023676609 modified "2023-10-18" @default.
- W2023676609 title "Squalene ameliorates atherosclerotic lesions through the reduction of CD36 scavenger receptor expression in macrophages" @default.
- W2023676609 cites W1965452003 @default.
- W2023676609 cites W1965864205 @default.
- W2023676609 cites W1974073985 @default.
- W2023676609 cites W1976621212 @default.
- W2023676609 cites W1986406816 @default.
- W2023676609 cites W1993987892 @default.
- W2023676609 cites W1999582366 @default.
- W2023676609 cites W2003050024 @default.
- W2023676609 cites W2005435407 @default.
- W2023676609 cites W2011167340 @default.
- W2023676609 cites W2012864140 @default.
- W2023676609 cites W2013285507 @default.
- W2023676609 cites W2018539384 @default.
- W2023676609 cites W2028716263 @default.
- W2023676609 cites W2030354555 @default.
- W2023676609 cites W2052613332 @default.
- W2023676609 cites W2057687709 @default.
- W2023676609 cites W2057776973 @default.
- W2023676609 cites W2058023006 @default.
- W2023676609 cites W2066963386 @default.
- W2023676609 cites W2078532650 @default.
- W2023676609 cites W2098285021 @default.
- W2023676609 cites W2113596164 @default.
- W2023676609 cites W2113606520 @default.
- W2023676609 cites W2115733867 @default.
- W2023676609 cites W2117345276 @default.
- W2023676609 cites W2118944124 @default.
- W2023676609 cites W2126794655 @default.
- W2023676609 cites W2142538883 @default.
- W2023676609 cites W2143668888 @default.
- W2023676609 cites W2146784855 @default.
- W2023676609 cites W2147410313 @default.
- W2023676609 cites W2151423964 @default.
- W2023676609 cites W2158921465 @default.
- W2023676609 cites W2161710155 @default.
- W2023676609 cites W2170644229 @default.
- W2023676609 cites W2212323528 @default.
- W2023676609 cites W4254629698 @default.
- W2023676609 cites W4256475235 @default.
- W2023676609 doi "https://doi.org/10.1002/mnfr.201100703" @default.
- W2023676609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22648620" @default.
- W2023676609 hasPublicationYear "2012" @default.
- W2023676609 type Work @default.
- W2023676609 sameAs 2023676609 @default.
- W2023676609 citedByCount "32" @default.
- W2023676609 countsByYear W20236766092012 @default.
- W2023676609 countsByYear W20236766092013 @default.
- W2023676609 countsByYear W20236766092015 @default.
- W2023676609 countsByYear W20236766092016 @default.
- W2023676609 countsByYear W20236766092017 @default.
- W2023676609 countsByYear W20236766092018 @default.
- W2023676609 countsByYear W20236766092019 @default.
- W2023676609 countsByYear W20236766092020 @default.
- W2023676609 countsByYear W20236766092021 @default.
- W2023676609 countsByYear W20236766092022 @default.
- W2023676609 countsByYear W20236766092023 @default.
- W2023676609 crossrefType "journal-article" @default.
- W2023676609 hasAuthorship W2023676609A5023918274 @default.
- W2023676609 hasAuthorship W2023676609A5036812594 @default.
- W2023676609 hasAuthorship W2023676609A5042190205 @default.
- W2023676609 hasAuthorship W2023676609A5055097306 @default.
- W2023676609 hasAuthorship W2023676609A5057137058 @default.
- W2023676609 hasAuthorship W2023676609A5061138653 @default.
- W2023676609 hasAuthorship W2023676609A5080829001 @default.
- W2023676609 hasConcept C108634530 @default.
- W2023676609 hasConcept C153911025 @default.
- W2023676609 hasConcept C154317977 @default.
- W2023676609 hasConcept C170493617 @default.
- W2023676609 hasConcept C185592680 @default.
- W2023676609 hasConcept C190283241 @default.
- W2023676609 hasConcept C195794163 @default.
- W2023676609 hasConcept C202751555 @default.
- W2023676609 hasConcept C203014093 @default.
- W2023676609 hasConcept C204232928 @default.
- W2023676609 hasConcept C204258353 @default.
- W2023676609 hasConcept C2775881703 @default.
- W2023676609 hasConcept C2776460901 @default.
- W2023676609 hasConcept C2776703722 @default.
- W2023676609 hasConcept C2777895019 @default.
- W2023676609 hasConcept C2778004101 @default.
- W2023676609 hasConcept C2778163477 @default.
- W2023676609 hasConcept C2779244956 @default.
- W2023676609 hasConcept C2779828298 @default.
- W2023676609 hasConcept C2780043322 @default.
- W2023676609 hasConcept C2780072125 @default.
- W2023676609 hasConcept C2781184567 @default.