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- W2023677360 endingPage "3300" @default.
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- W2023677360 abstract "A highly divergent route to a variety of quinolizidine alkaloids is described. The enantiomeric precursors 22a and 22b utilized for the synthesis of these alkaloids were constructed stereospecifically from the PET cyclization of the corresponding acetylene tethered α-trimethylsilyl amine moieties 21a and 21b, respectively, both of which were synthesised from D-ribose. The polyhydroxy quinolizidine alkaloid 7 was found to be a selective inhibitor of α-galactosidase with Ki 83.9 μM. The amine analogs 18, 12 and 10 are found to be selective and potent inhibitors of α-glucosidase with Ki 28, 120 and 140 μM, respectively." @default.
- W2023677360 created "2016-06-24" @default.
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- W2023677360 date "2009-01-01" @default.
- W2023677360 modified "2023-10-17" @default.
- W2023677360 title "Synthesis of polyfunctional quinolizidine alkaloids: development towards selective glycosidase inhibitors" @default.
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- W2023677360 doi "https://doi.org/10.1039/b907007a" @default.
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