FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023677573> ?p ?o ?g. }

• W2023677573 endingPage "2571" @default.
• W2023677573 startingPage "2552" @default.
• W2023677573 abstract "Choline plays a lipotropic role in lipid metabolism as an essential nutrient. In this study, we investigated the effects of choline (5, 35 and 70 μM) on DNA methylation modifications, mRNA expression of the critical genes and their enzyme activities involved in hepatic lipid metabolism, mitochondrial membrane potential (Δψm) and glutathione peroxidase (GSH-Px) in C3A cells exposed to excessive energy substrates (lactate, 10 mM; octanoate, 2 mM and pyruvate, 1 mM; lactate, octanoate and pyruvate-supplemented medium (LOP)). Thirty five micromole or 70 μM choline alone, instead of a low dose (5 μM), reduced hepatocellular triglyceride (TG) accumulation, protected Δψm from decrement and increased GSH-Px activity in C3A cells. The increment of TG accumulation, reactive oxygen species (ROS) production and Δψm disruption were observed under LOP treatment in C3A cells after 72 h of culture, which were counteracted by concomitant treatment of choline (35 μM or 70 μM) partially via reversing the methylation status of the peroxisomal proliferator-activated receptor alpha (PPARα) gene promoter, upregulating PPARα, carnitine palmitoyl transferase-I (CPT-I) and downregulating fatty acid synthase (FAS) gene expression, as well as decreasing FAS activity and increasing CPT-I and GSH-Px activities. These findings provided a novel insight into the lipotropic role of choline as a vital methyl-donor in the intervention of chronic metabolic diseases." @default.
• W2023677573 created "2016-06-24" @default.
• W2023677573 creator A5022083751 @default.
• W2023677573 creator A5033480643 @default.
• W2023677573 creator A5035124018 @default.
• W2023677573 creator A5068435349 @default.
• W2023677573 creator A5069509754 @default.
• W2023677573 date "2014-07-09" @default.
• W2023677573 modified "2023-09-27" @default.
• W2023677573 title "The Effects of Choline on Hepatic Lipid Metabolism, Mitochondrial Function and Antioxidative Status in Human Hepatic C3A Cells Exposed to Excessive Energy Substrates" @default.
• W2023677573 cites W1874317773 @default.
• W2023677573 cites W1916320982 @default.
• W2023677573 cites W1975053400 @default.
• W2023677573 cites W1975962309 @default.
• W2023677573 cites W1977340713 @default.
• W2023677573 cites W1991480048 @default.
• W2023677573 cites W1999514106 @default.
• W2023677573 cites W2002613261 @default.
• W2023677573 cites W2007759293 @default.
• W2023677573 cites W2010645487 @default.
• W2023677573 cites W2012886521 @default.
• W2023677573 cites W2013446239 @default.
• W2023677573 cites W2013635918 @default.
• W2023677573 cites W2018040358 @default.
• W2023677573 cites W2018915889 @default.
• W2023677573 cites W2031002674 @default.
• W2023677573 cites W2032017606 @default.
• W2023677573 cites W2035588804 @default.
• W2023677573 cites W2042555983 @default.
• W2023677573 cites W2055878421 @default.
• W2023677573 cites W2063148024 @default.
• W2023677573 cites W2065886025 @default.
• W2023677573 cites W2066727736 @default.
• W2023677573 cites W2068072153 @default.
• W2023677573 cites W2070463636 @default.
• W2023677573 cites W2071457248 @default.
• W2023677573 cites W2076452736 @default.
• W2023677573 cites W2077271774 @default.
• W2023677573 cites W2081028309 @default.
• W2023677573 cites W2092267358 @default.
• W2023677573 cites W2098111353 @default.
• W2023677573 cites W2106372090 @default.
• W2023677573 cites W2120886362 @default.
• W2023677573 cites W2155201378 @default.
• W2023677573 cites W2160089607 @default.
• W2023677573 cites W2161246973 @default.
• W2023677573 cites W2162051951 @default.
• W2023677573 cites W2162233993 @default.
• W2023677573 cites W2164118055 @default.
• W2023677573 cites W2166757392 @default.
• W2023677573 cites W4255769967 @default.
• W2023677573 doi "https://doi.org/10.3390/nu6072552" @default.
• W2023677573 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4113756" @default.
• W2023677573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25010553" @default.
• W2023677573 hasPublicationYear "2014" @default.
• W2023677573 type Work @default.
• W2023677573 sameAs 2023677573 @default.
• W2023677573 citedByCount "47" @default.
• W2023677573 countsByYear W20236775732015 @default.
• W2023677573 countsByYear W20236775732016 @default.
• W2023677573 countsByYear W20236775732017 @default.
• W2023677573 countsByYear W20236775732018 @default.
• W2023677573 countsByYear W20236775732019 @default.
• W2023677573 countsByYear W20236775732020 @default.
• W2023677573 countsByYear W20236775732021 @default.
• W2023677573 countsByYear W20236775732022 @default.
• W2023677573 countsByYear W20236775732023 @default.
• W2023677573 crossrefType "journal-article" @default.
• W2023677573 hasAuthorship W2023677573A5022083751 @default.
• W2023677573 hasAuthorship W2023677573A5033480643 @default.
• W2023677573 hasAuthorship W2023677573A5035124018 @default.
• W2023677573 hasAuthorship W2023677573A5068435349 @default.
• W2023677573 hasAuthorship W2023677573A5069509754 @default.
• W2023677573 hasBestOaLocation W20236775731 @default.
• W2023677573 hasConcept C126322002 @default.
• W2023677573 hasConcept C134018914 @default.
• W2023677573 hasConcept C181199279 @default.
• W2023677573 hasConcept C185592680 @default.
• W2023677573 hasConcept C2776423169 @default.
• W2023677573 hasConcept C2778435403 @default.
• W2023677573 hasConcept C2778760513 @default.
• W2023677573 hasConcept C2781123555 @default.
• W2023677573 hasConcept C4733338 @default.
• W2023677573 hasConcept C538909803 @default.
• W2023677573 hasConcept C55493867 @default.
• W2023677573 hasConcept C62231903 @default.
• W2023677573 hasConcept C71924100 @default.
• W2023677573 hasConcept C82714985 @default.
• W2023677573 hasConcept C86803240 @default.
• W2023677573 hasConceptScore W2023677573C126322002 @default.
• W2023677573 hasConceptScore W2023677573C134018914 @default.
• W2023677573 hasConceptScore W2023677573C181199279 @default.
• W2023677573 hasConceptScore W2023677573C185592680 @default.
• W2023677573 hasConceptScore W2023677573C2776423169 @default.
• W2023677573 hasConceptScore W2023677573C2778435403 @default.
• W2023677573 hasConceptScore W2023677573C2778760513 @default.
• W2023677573 hasConceptScore W2023677573C2781123555 @default.
• W2023677573 hasConceptScore W2023677573C4733338 @default.

• next