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• W2023678813 abstract "The genome of Mycobacterium tuberculosis (TB) contains a gene that encodes a highly active β-lactamase, BlaC, that imparts TB with resistance to β-lactam chemotherapy. The structure of covalent BlaC-β-lactam complexes suggests that active site residues K73 and E166 are essential for acylation and deacylation, respectively. We have prepared the K73A and E166A mutant forms of BlaC and have determined the structures of the Michaelis complex of cefamandole and the covalently bound acyl intermediate of cefamandole at resolutions of 1.2 and 2.0 Å, respectively. These structures provide insight into the details of the catalytic mechanism." @default.
• W2023678813 created "2016-06-24" @default.
• W2023678813 creator A5020083066 @default.
• W2023678813 creator A5047974197 @default.
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• W2023678813 date "2010-11-16" @default.
• W2023678813 modified "2023-10-16" @default.
• W2023678813 title "Structures of the Michaelis complex (1.2 Å) and the covalent acyl intermediate (2.0 Å) of cefamandole bound in the active sites of the Mycobacterium tuberculosis β-lactamase K73A and E166A mutants." @default.
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• W2023678813 doi "https://doi.org/10.1021/bi1015088" @default.
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