FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023680003> ?p ?o ?g. }

• W2023680003 endingPage "865" @default.
• W2023680003 startingPage "859" @default.
• W2023680003 abstract "Muscle acetylcholine receptors are synaptic ion channels that “gate” between closed- and open-channel conformations. We used Φ-value analysis to probe the transition state of the diliganded gating reaction with regard to residues in the M3, membrane-spanning helix of the muscle acetylcholine receptor α-subunit. Φ (a fraction between 1 and 0) parameterizes the extent to which a mutation changes the opening versus the closing rate constant and, for a linear reaction mechanism, the higher the Φ-value, the “earlier” the gating motion. In the upper half of αM3 the gating motions of all five tested residues were temporally correlated (Φ ≈ 0.30) and serve to link structural changes occurring at the middle of the M2, pore-lining helix with those occurring at the interface of the extracellular and transmembrane domains. αM3 belongs to a complex and diverse set of synchronously moving parts that change structure relatively late in the channel-opening process. The propagation of the gating Brownian conformational cascade has a complex spatial distribution in the transmembrane domain." @default.
• W2023680003 created "2016-06-24" @default.
• W2023680003 creator A5014752870 @default.
• W2023680003 creator A5064835126 @default.
• W2023680003 date "2007-08-01" @default.
• W2023680003 modified "2023-10-15" @default.
• W2023680003 title "Conformational Dynamics of the αM3 Transmembrane Helix during Acetylcholine Receptor Channel Gating" @default.
• W2023680003 cites W1492943506 @default.
• W2023680003 cites W1550693429 @default.
• W2023680003 cites W1564990428 @default.
• W2023680003 cites W1632324362 @default.
• W2023680003 cites W1969593771 @default.
• W2023680003 cites W1971191923 @default.
• W2023680003 cites W1974558307 @default.
• W2023680003 cites W1981857440 @default.
• W2023680003 cites W1989392648 @default.
• W2023680003 cites W1998441265 @default.
• W2023680003 cites W1999793963 @default.
• W2023680003 cites W2000860313 @default.
• W2023680003 cites W2005843451 @default.
• W2023680003 cites W2009955424 @default.
• W2023680003 cites W2010379824 @default.
• W2023680003 cites W2012605007 @default.
• W2023680003 cites W2019783925 @default.
• W2023680003 cites W2026162708 @default.
• W2023680003 cites W2027664610 @default.
• W2023680003 cites W2028592856 @default.
• W2023680003 cites W2028741068 @default.
• W2023680003 cites W2028920824 @default.
• W2023680003 cites W2032472801 @default.
• W2023680003 cites W2032892621 @default.
• W2023680003 cites W2035482934 @default.
• W2023680003 cites W2042940622 @default.
• W2023680003 cites W2056778461 @default.
• W2023680003 cites W2067957221 @default.
• W2023680003 cites W2087600888 @default.
• W2023680003 cites W2101887667 @default.
• W2023680003 cites W2125656357 @default.
• W2023680003 cites W2130881414 @default.
• W2023680003 cites W2133457325 @default.
• W2023680003 cites W2143014450 @default.
• W2023680003 cites W2159006731 @default.
• W2023680003 cites W2160251618 @default.
• W2023680003 cites W2163724463 @default.
• W2023680003 doi "https://doi.org/10.1529/biophysj.107.105171" @default.
• W2023680003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1913136" @default.
• W2023680003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17513382" @default.
• W2023680003 hasPublicationYear "2007" @default.
• W2023680003 type Work @default.
• W2023680003 sameAs 2023680003 @default.
• W2023680003 citedByCount "17" @default.
• W2023680003 countsByYear W20236800032012 @default.
• W2023680003 countsByYear W20236800032013 @default.
• W2023680003 countsByYear W20236800032016 @default.
• W2023680003 countsByYear W20236800032017 @default.
• W2023680003 crossrefType "journal-article" @default.
• W2023680003 hasAuthorship W2023680003A5014752870 @default.
• W2023680003 hasAuthorship W2023680003A5064835126 @default.
• W2023680003 hasBestOaLocation W20236800031 @default.
• W2023680003 hasConcept C118892022 @default.
• W2023680003 hasConcept C12554922 @default.
• W2023680003 hasConcept C134018914 @default.
• W2023680003 hasConcept C170493617 @default.
• W2023680003 hasConcept C185592680 @default.
• W2023680003 hasConcept C18903297 @default.
• W2023680003 hasConcept C194544171 @default.
• W2023680003 hasConcept C24530287 @default.
• W2023680003 hasConcept C2775910092 @default.
• W2023680003 hasConcept C2777339483 @default.
• W2023680003 hasConcept C2778530040 @default.
• W2023680003 hasConcept C2779965526 @default.
• W2023680003 hasConcept C50254741 @default.
• W2023680003 hasConcept C55493867 @default.
• W2023680003 hasConcept C71240020 @default.
• W2023680003 hasConcept C8010536 @default.
• W2023680003 hasConcept C80161118 @default.
• W2023680003 hasConcept C86803240 @default.
• W2023680003 hasConceptScore W2023680003C118892022 @default.
• W2023680003 hasConceptScore W2023680003C12554922 @default.
• W2023680003 hasConceptScore W2023680003C134018914 @default.
• W2023680003 hasConceptScore W2023680003C170493617 @default.
• W2023680003 hasConceptScore W2023680003C185592680 @default.
• W2023680003 hasConceptScore W2023680003C18903297 @default.
• W2023680003 hasConceptScore W2023680003C194544171 @default.
• W2023680003 hasConceptScore W2023680003C24530287 @default.
• W2023680003 hasConceptScore W2023680003C2775910092 @default.
• W2023680003 hasConceptScore W2023680003C2777339483 @default.
• W2023680003 hasConceptScore W2023680003C2778530040 @default.
• W2023680003 hasConceptScore W2023680003C2779965526 @default.
• W2023680003 hasConceptScore W2023680003C50254741 @default.
• W2023680003 hasConceptScore W2023680003C55493867 @default.
• W2023680003 hasConceptScore W2023680003C71240020 @default.
• W2023680003 hasConceptScore W2023680003C8010536 @default.
• W2023680003 hasConceptScore W2023680003C80161118 @default.
• W2023680003 hasConceptScore W2023680003C86803240 @default.
• W2023680003 hasIssue "3" @default.
• W2023680003 hasLocation W20236800031 @default.
• W2023680003 hasLocation W20236800032 @default.

• next