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• W2023681435 endingPage "447" @default.
• W2023681435 startingPage "437" @default.
• W2023681435 abstract "Contact is a vital mechanism used by cells to interact with their environment. Contact with living and nonliving elements adjacent to a cell is the basis for many common biological events ranging from growth regulation to metastasis to embryonic pattern formation. We describe the cloning and characterization of a novel density-regulated protein (drp) whose expression is increased in cultured cells at high density compared with cells at low density. A drp cDNA was isolated from the human teratocarcinoma cell line PA-1. Northern analysis with a drp probe revealed transcripts of 2.8 and 3.2 kb. The drp RNA was expressed in a variety of tissues, with the highest amounts in skeletal and cardiac muscle. Using antipeptide antisera, increasing amounts of a 70-kDa protein were detected using several experimental approaches in several cells lines as cell density is increased. Conditioned medium from high-density cells was unable to induce expression of drp in cells growing at low density. Similarly, growth arrest by serum starvation or transforming growth factor-β (TGF-β) treatment failed to elicit drp expression. We conclude that drp is a novel protein whose expression is increased at high cell density but not growth arrest." @default.
• W2023681435 created "2016-06-24" @default.
• W2023681435 creator A5052296926 @default.
• W2023681435 creator A5065937259 @default.
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• W2023681435 date "1998-05-01" @default.
• W2023681435 modified "2023-10-16" @default.
• W2023681435 title "drp, a Novel Protein Expressed at High Cell Density but Not During Growth Arrest" @default.
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• W2023681435 doi "https://doi.org/10.1089/dna.1998.17.437" @default.
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