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- W2023682196 abstract "The recent obesity epidemic among children and adolescents is alarming. Not only is obesity associated with increased risk of insulin resistance and diabetes, but it is also linked to numerous complications. The mechanisms that might contribute to obesity complications in the growing child are yet unknown, but mounting evidence suggests a role for adipose derived cytokines like interleukin-6 (IL-6), leptin and the recently discovered adiponectin. PURPOSE To test the hypothesis that these mediators are related to body composition and fitness in adolescent females. METHODS We measured these cytokines in 64 healthy adolescent females (mean age 15.1 ± 0.1 years, BMI% 65.2 ± 3.2). These values were correlated with BMI and BMI as age-determined percentile; DEXA as percent body fat; and fitness level as determined by a standard exercise test. RESULTS Adiponectin (mean 10.3 ± 0.5 mg/ml) was inversely correlated with each estimate of fat (BMI r = −0.53, p = 0.0005; BMI% r = −0.44, p = 0.0005; DEXA r = −0.43, p = 0.0005). Leptin was positively correlated with indices of obesity (BMI, r = 0.69, p = 0.0005; BMI% r = 0.63, p = 0.0005; DEXA r = 0.7, p = 0.0005). Counterintuitively, fitness was negatively correlated with adiponectin (r = −0.4, p = 0.001) and positively correlated with leptin (r = 0.38, p = 0.007). IL-6 was positively correlated with both BMI% and fat mass (r = 0.446, p = 0.002 and r = 0.545, p = 0.0005 respectively) and negatively correlated with fitness (r = 0.427, p = 0.04). CONCLUSION These data represent the first report of adiponectin in adolescent females. Circulating levels of fat derived cytokines are correlated with fat mass and fitness in adolescent girls. These relationships suggest that pathologic mechanisms linking obesity to disease are present early in life. Sponsored by NIH grants MO1-RR00827 and HD23969 and HD37746-02." @default.
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- W2023682196 date "2003-05-01" @default.
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- W2023682196 title "RELATIONSHIPS AMONG ADIPONECTIN AND OTHER ADIPOSE CYTOKINES, BODY COMPOSITION, AND FITNESS IN ADOLESCENT FEMALES." @default.
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