FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023682663> ?p ?o ?g. }

• W2023682663 endingPage "115" @default.
• W2023682663 startingPage "111" @default.
• W2023682663 abstract "All forms of transplantation except autografts and transplants between genetically identical twins involve crossing genetically encoded barriers. In allotransplantation we try to lower the barriers by a variety of means: we match the major histocompatibility genes and the blood groups of donor-recipient pairs and perform crossmatches to minimise the effects of prior sensitisation to any HLA antigens which may be mismatched. We prefer related over unrelated donors, because the former pick up some matches not only for what we know but inadvertently for unknown but nevertheless relevant genetic differences. Despite these efforts we still have to overcome the effects of other unmatched, untested or unknown genetic differences by immunosuppressing the recipient; this is not always successful and always comes at a price.Of course xenotransplantation is no exception and what is more the genetically encoded barriers are even higher. However, because a pig is a pig and not a human we can directly attack the genetic barriers – we can genetically modify the pig and so provide a genetic solution to a genetic problem and even go a little further.We generally think of potential genetic modifications under headings based on the technology employed: gene knockouts – to remove particular pig characteristics, archetypically the αGal epitope; and transgenesis – to add human characteristics to the pig tissue e.g. the human complement regulator DAF. However to be comprehensive we need to broaden that view and one approach is to think of genetic modifications as either prophylactic or therapeutic. This allows us to take advantage of the enormous power of genetic engineering and to think about making changes which go beyond simply trying to make the pig donor tissue a little more like a human allograft i.e. beyond prophylactic modifications. Some therapeutic genetic modifications may even overcome problems which still are an issue in allotransplantation e.g. local expression of immunosuppressive molecules within xenografts may minimise the need for systemic immunosuppression." @default.
• W2023682663 created "2016-06-24" @default.
• W2023682663 creator A5039238202 @default.
• W2023682663 creator A5067910050 @default.
• W2023682663 date "2009-06-01" @default.
• W2023682663 modified "2023-10-15" @default.
• W2023682663 title "Xenotransplantation: The next generation of engineered animals" @default.
• W2023682663 cites W1752100137 @default.
• W2023682663 cites W1845094941 @default.
• W2023682663 cites W1974164654 @default.
• W2023682663 cites W1975251263 @default.
• W2023682663 cites W1981498160 @default.
• W2023682663 cites W1999416747 @default.
• W2023682663 cites W2016124159 @default.
• W2023682663 cites W2018204952 @default.
• W2023682663 cites W2041804953 @default.
• W2023682663 cites W2042288895 @default.
• W2023682663 cites W2044017101 @default.
• W2023682663 cites W2044352498 @default.
• W2023682663 cites W2051316634 @default.
• W2023682663 cites W2061229416 @default.
• W2023682663 cites W2062464221 @default.
• W2023682663 cites W2072247930 @default.
• W2023682663 cites W2074332806 @default.
• W2023682663 cites W2081660148 @default.
• W2023682663 cites W2083804112 @default.
• W2023682663 cites W2092178015 @default.
• W2023682663 cites W2092729744 @default.
• W2023682663 cites W2104958181 @default.
• W2023682663 cites W2110762398 @default.
• W2023682663 cites W2118643867 @default.
• W2023682663 cites W2122136738 @default.
• W2023682663 cites W2142145484 @default.
• W2023682663 cites W2150064989 @default.
• W2023682663 cites W2150083988 @default.
• W2023682663 cites W2152232578 @default.
• W2023682663 cites W2161754485 @default.
• W2023682663 cites W2163788588 @default.
• W2023682663 cites W2166408713 @default.
• W2023682663 cites W2169901386 @default.
• W2023682663 cites W2235148149 @default.
• W2023682663 cites W2429658547 @default.
• W2023682663 cites W4253320561 @default.
• W2023682663 doi "https://doi.org/10.1016/j.trim.2008.10.003" @default.
• W2023682663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2727646" @default.
• W2023682663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18973810" @default.
• W2023682663 hasPublicationYear "2009" @default.
• W2023682663 type Work @default.
• W2023682663 sameAs 2023682663 @default.
• W2023682663 citedByCount "28" @default.
• W2023682663 countsByYear W20236826632012 @default.
• W2023682663 countsByYear W20236826632013 @default.
• W2023682663 countsByYear W20236826632014 @default.
• W2023682663 countsByYear W20236826632015 @default.
• W2023682663 countsByYear W20236826632016 @default.
• W2023682663 countsByYear W20236826632017 @default.
• W2023682663 countsByYear W20236826632018 @default.
• W2023682663 crossrefType "journal-article" @default.
• W2023682663 hasAuthorship W2023682663A5039238202 @default.
• W2023682663 hasAuthorship W2023682663A5067910050 @default.
• W2023682663 hasBestOaLocation W20236826632 @default.
• W2023682663 hasConcept C126322002 @default.
• W2023682663 hasConcept C2778442404 @default.
• W2023682663 hasConcept C2911091166 @default.
• W2023682663 hasConcept C41008148 @default.
• W2023682663 hasConcept C70721500 @default.
• W2023682663 hasConcept C71924100 @default.
• W2023682663 hasConcept C86803240 @default.
• W2023682663 hasConceptScore W2023682663C126322002 @default.
• W2023682663 hasConceptScore W2023682663C2778442404 @default.
• W2023682663 hasConceptScore W2023682663C2911091166 @default.
• W2023682663 hasConceptScore W2023682663C41008148 @default.
• W2023682663 hasConceptScore W2023682663C70721500 @default.
• W2023682663 hasConceptScore W2023682663C71924100 @default.
• W2023682663 hasConceptScore W2023682663C86803240 @default.
• W2023682663 hasIssue "2" @default.
• W2023682663 hasLocation W20236826631 @default.
• W2023682663 hasLocation W20236826632 @default.
• W2023682663 hasLocation W20236826633 @default.
• W2023682663 hasLocation W20236826634 @default.
• W2023682663 hasOpenAccess W2023682663 @default.
• W2023682663 hasPrimaryLocation W20236826631 @default.
• W2023682663 hasRelatedWork W1489857015 @default.
• W2023682663 hasRelatedWork W2001833660 @default.
• W2023682663 hasRelatedWork W2064454978 @default.
• W2023682663 hasRelatedWork W2082860237 @default.
• W2023682663 hasRelatedWork W2353982441 @default.
• W2023682663 hasRelatedWork W2427173486 @default.
• W2023682663 hasRelatedWork W2748952813 @default.
• W2023682663 hasRelatedWork W2899084033 @default.
• W2023682663 hasRelatedWork W4386761976 @default.
• W2023682663 hasRelatedWork W873940110 @default.
• W2023682663 hasVolume "21" @default.
• W2023682663 isParatext "false" @default.
• W2023682663 isRetracted "false" @default.
• W2023682663 magId "2023682663" @default.
• W2023682663 workType "article" @default.