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• W2023683172 abstract "A blood biomarker of omega-3 fatty acid intake and tissue status could serve as a modifiable risk factor for cardiovascular disease. The percentage of omega-3 highly unsaturated fatty acid (HUFA ≥ 20 carbons and ≥3 double bonds) in the total HUFA pool (the n-3 HUFA score) was examined as a potential blood biomarker of omega-3 fatty acids in tissues. The fatty acid composition of total lipid extracts (TLE) and phospholipid (PL) fractions were determined for plasma and erythrocytes samples of human subjects (n = 20) and the n-3 HUFA score and the sum of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were compared. Omega-3 fatty acids in blood and tissues of rats (n = 31) and pigs (n = 48) were also determined and the associations were compared. The n-3 HUFA score is more consistent across plasma and erythrocytes, with strong correlations between TLE and PL in plasma (r = 0.93) and erythrocytes (r = 0.94). The n-3 HUFA score was less variable and blood levels correlated strongly with various animal tissues. The n-3 HUFA score is a useful blood biomarker that does not require the isolation of the PL class thereby supporting high throughput analyses. The strength of association between the n-3 HUFA score and disease risk needs to be examined." @default.
• W2023683172 created "2016-06-24" @default.
• W2023683172 creator A5037500176 @default.
• W2023683172 date "2007-11-06" @default.
• W2023683172 modified "2023-10-04" @default.
• W2023683172 title "The Percentage of n-3 Highly Unsaturated Fatty Acids in Total HUFA as a Biomarker for Omega-3 Fatty Acid Status in Tissues" @default.
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• W2023683172 doi "https://doi.org/10.1007/s11745-007-3128-3" @default.
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