FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023683752> ?p ?o ?g. }

• W2023683752 endingPage "e579" @default.
• W2023683752 startingPage "e578" @default.
• W2023683752 abstract "Editor, We congratulate Ilgninis and co-authors for their interesting article describing the prevalence of polypoidal choroidal vasculopathy (PCV) in a series of hospital patients in Denmark (Ilginis et al. 2012). While the prevalence of PCV in Western populations is generally reported to be lower than among Asians (Lim et al. 2010), the results reported by Ilginis et al. (2012) and other authors confirm that PCV is an important condition in Western populations, accounting for up to 10% of patients presenting as neovascular age-related macular degeneration (AMD) (Lim et al. 2010). We agree with the authors that the prevalence of PCV may be under-diagnosed in some populations and would like to stress the importance of indocyanine green angiography (ICGA) in the investigations of patients presenting with signs of neovascular AMD, especially if they have previously been treated and appear refractory to standard intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) agents. There have been several reports of patients with presumed AMD who were unresponsive to anti-VEGF treatment. The diagnosis of PCV was subsequently confirmed when ICGA was performed (Cho et al. 2009; Stangos et al. 2010). It has been suggested that modifications in therapeutic protocols may be required to improve visual and anatomical outcomes in these patients (Cho et al. 2009). It is important to differentiate PCV from neovascular AMD because the EVEREST study (Koh et al. 2012) has demonstrated that the optimal treatment of PCV differs from AMD, with a higher rate of polyp closure achieved with combination therapy of photodynamic therapy (PDT) and anti-VEGF injections compared to treatment with anti-VEGF monotherapy. The EVERST study, however, only assessed outcomes up to 6 months. Some authors have suggested that repeated PDT monotherapy has limitations as a long-term treatment for PCV and suggested the concurrent use of anti-VEGF agents (Yuzawa 2012). The variability in visual outcomes of PDT treatment for PCV may be due to the existence of different subgroups of PCV. Yuzawa reported two subgroups of PCV, the first with both feeder and draining vessels, and network vessels showing characteristic findings of choroidal neovascularization (CNV) (Yuzawa 2012). The second pattern had neither feeder nor draining vessels, and there were few network vessels. The former, termed polypoidal CNV, was associated with the ARMS 2(A69S) gene and is thought to represent a deformation of the CNV under the retinal pigment epithelium. In contrast, the latter, termed PCV in the strict sense, was not associated with the ARMS 2 gene and was characterized by hyalinized arteriolosclerosis of choroidal vessels (Yuzawa 2012). The authors reported that the appearance of an orange–red nodule on ophthalmoscopy and dynamic (video) ICGA were not used as diagnostic criteria in their study (Ilginis et al. 2012). We would like to highlight the importance of both these features, which are among the six diagnostic criteria for PCV which was used in the EVEREST study (Lim et al. 2010; Koh et al. 2012). Dynamic video angiography allows visualization of the early filling patterns of the choroidal vessels, where abnormal branching vascular networks are most clearly seen. As the authors stated, pulsation of the polyps can also be seen with video angiography. While we agree that orange nodules may sometimes not be seen clearly on fundus photography due to factors such as media opacity, it may be possible to detect orange–red subretinal nodules on clinical examination. In a series of 80 patients seen in our practice, orange–red nodules were seen in 48% of cases, thus illustrating its usefulness as a diagnostic criteria. Spectral domain optical coherence tomography (OCT) is likely to play an increasingly important role in the diagnosis of PCV. Simultaneous scanning laser ophthalmoscope ICGA and OCT was found to be useful in the diagnosis of PCV, and it has been reported that the majority of PCV in that series represented a variant of Type 1 neovascular growth pattern (Khan et al. 2012). In summary, we congratulate the authors for investigating the prevalence of PCV in Scandinavian populations and would like to emphasize the role of ICGA and other imaging modalities in diagnosing PCV among patients presenting with clinical signs of neovascular AMD." @default.
• W2023683752 created "2016-06-24" @default.
• W2023683752 creator A5012319324 @default.
• W2023683752 creator A5052829344 @default.
• W2023683752 creator A5056006138 @default.
• W2023683752 creator A5090849792 @default.
• W2023683752 date "2013-06-20" @default.
• W2023683752 modified "2023-09-23" @default.
• W2023683752 title "Polypoidal Choroidal Vasculopathy in patients diagnosed with age-related macular degeneration" @default.
• W2023683752 cites W1976433015 @default.
• W2023683752 cites W2011653842 @default.
• W2023683752 cites W2026338952 @default.
• W2023683752 cites W2030010468 @default.
• W2023683752 cites W2105442461 @default.
• W2023683752 cites W2136039929 @default.
• W2023683752 doi "https://doi.org/10.1111/aos.12214" @default.
• W2023683752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23782725" @default.
• W2023683752 hasPublicationYear "2013" @default.
• W2023683752 type Work @default.
• W2023683752 sameAs 2023683752 @default.
• W2023683752 citedByCount "2" @default.
• W2023683752 countsByYear W20236837522014 @default.
• W2023683752 countsByYear W20236837522015 @default.
• W2023683752 crossrefType "journal-article" @default.
• W2023683752 hasAuthorship W2023683752A5012319324 @default.
• W2023683752 hasAuthorship W2023683752A5052829344 @default.
• W2023683752 hasAuthorship W2023683752A5056006138 @default.
• W2023683752 hasAuthorship W2023683752A5090849792 @default.
• W2023683752 hasBestOaLocation W20236837521 @default.
• W2023683752 hasConcept C118487528 @default.
• W2023683752 hasConcept C121332964 @default.
• W2023683752 hasConcept C142424586 @default.
• W2023683752 hasConcept C187212893 @default.
• W2023683752 hasConcept C2776403814 @default.
• W2023683752 hasConcept C2778257484 @default.
• W2023683752 hasConcept C2780248432 @default.
• W2023683752 hasConcept C2910234007 @default.
• W2023683752 hasConcept C71924100 @default.
• W2023683752 hasConcept C87355193 @default.
• W2023683752 hasConceptScore W2023683752C118487528 @default.
• W2023683752 hasConceptScore W2023683752C121332964 @default.
• W2023683752 hasConceptScore W2023683752C142424586 @default.
• W2023683752 hasConceptScore W2023683752C187212893 @default.
• W2023683752 hasConceptScore W2023683752C2776403814 @default.
• W2023683752 hasConceptScore W2023683752C2778257484 @default.
• W2023683752 hasConceptScore W2023683752C2780248432 @default.
• W2023683752 hasConceptScore W2023683752C2910234007 @default.
• W2023683752 hasConceptScore W2023683752C71924100 @default.
• W2023683752 hasConceptScore W2023683752C87355193 @default.
• W2023683752 hasIssue "7" @default.
• W2023683752 hasLocation W20236837521 @default.
• W2023683752 hasLocation W20236837522 @default.
• W2023683752 hasOpenAccess W2023683752 @default.
• W2023683752 hasPrimaryLocation W20236837521 @default.
• W2023683752 hasRelatedWork W2353073628 @default.
• W2023683752 hasRelatedWork W2358368377 @default.
• W2023683752 hasRelatedWork W2364284743 @default.
• W2023683752 hasRelatedWork W2365176743 @default.
• W2023683752 hasRelatedWork W2372379503 @default.
• W2023683752 hasRelatedWork W2374960928 @default.
• W2023683752 hasRelatedWork W2565869648 @default.
• W2023683752 hasRelatedWork W2737406939 @default.
• W2023683752 hasRelatedWork W3031319851 @default.
• W2023683752 hasRelatedWork W4312058799 @default.
• W2023683752 hasVolume "91" @default.
• W2023683752 isParatext "false" @default.
• W2023683752 isRetracted "false" @default.
• W2023683752 magId "2023683752" @default.
• W2023683752 workType "article" @default.