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- W2023684178 abstract "Background: Chemokine-driven migration of inflammatory cells has been implicated in the pathogenesis of atherosclerotic conditions including peripheral arterial disease (PAD). Monocyte chemoattractant protein-1 (MCP-1) is elevated in patients with coronary artery disease and in hypertensive patients. This study therefore investigated MCP-1 in patients with PAD. Methods: Serum MCP-1 was determined by enzyme-linked immunosorbent assay in 36 healthy, control subjects and in 19 patients with PAD. Statistical analysis utilised the Mann-Whitney test and Spearman correlation<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML alttext=$left( {p < 0.05} right)$ id=E1><mml:mrow><mml:mrow><mml:mo>(</mml:mo><mml:mrow><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow><mml:mo>)</mml:mo></mml:mrow></mml:mrow></mml:math>. Results: MCP-1 (pg/ml) was increased in patients compared with in controls (mean±standard error of the mean: PAD group, 748±60; control group, 459±27; p=0.0001). MCP-1 levels tended to decrease with progressing disease. From atherosclerosis risk factors, diabetes inclined to increase MCP-1 levels; hypertension had no effect. Serum MCP-1 correlated with cholesterol, triglycerides, low-density lipoprotein but not high-density lipoprotein. Conclusion: Elevation of MCP-1 in the circulation of PAD patients shown in the present pilot study implicates this CC chemokine ligand 2 in inflammatory processes contributing to PAD clinical symptomatology. Further investigations are necessary to evaluate whether MCP-1 can be used as a potential marker of peripheral arterial disease follow-up and/or prognosis." @default.
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- W2023684178 date "2004-01-01" @default.
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- W2023684178 title "Monocyte chemoattractant protein-1 in patients with peripheral arterial disease" @default.
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- W2023684178 doi "https://doi.org/10.1080/09629350410001664752" @default.
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