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• W2023684680 abstract "Objectives: We hypothesized that the CD40/CD40 ligand (CD40L) system is up-regulated in the metabolic syndrome (MS) and modulated by adiponectin (AN). The objectives were: 1) to compare plasma and monocyte CD40L in patients with MS and controls and its association with clinical and biochemical parameters, 2) to investigate platelets as a source of soluble CD40L (sCD40L), and 3) to analyze the effects of AN on CD40/CD40L. Methods: Plasma sCD40L and AN were measured in 246 controls and 128 patients with MS by ELISA. Monocyte CD40/CD40L expression and platelet CD40L content and release were compared in patients with MS and controls. Monocytes and endothelial cells were cultured with AN and CD40/CD40L expression determined by real-time RT-PCR and Western blotting. Results: Patients with MS had higher sCD40L and lower AN levels than controls (0.89 ± 0.1 vs. 0.76 ± 0.07 ng/ml and 10.10 ± 0.65 vs. 12.99 ± 0.80 μg/ml, P < 0.05). Monocyte CD40/CD40L expression was higher (P < 0.05) in patients than controls (CD40: 1.31 ± 0.31 vs. 0.80 ± 0.14 arbitrary units; CD40L: 1.24 ± 0.85 vs. 0.43 ± 0.14 pg/μg protein). No differences were observed on CD40L content between resting platelets from patients with MS and controls (7.7 ± 3.5 vs. 7.2 ± 2.2 pg/μg protein). Stimulated platelets from patients with the MS released more (P < 0.05) sCD40L than controls (582 ± 141 vs. 334 ± 60% change vs. nonstimulated platelets). AN reduced CD40L mRNA and protein expression in monocytes from MS patients and endothelial cells. Conclusions: The enhanced sCD40L and cellular CD40L expression in the MS suggests that CD40L is of pathophysiological relevance in MS. Also, a new antiinflammatory effect of AN is described through the modulation of the CD40/CD40L system." @default.
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• W2023684680 date "2008-06-01" @default.
• W2023684680 modified "2023-10-16" @default.
• W2023684680 title "The Proinflammatory Mediator CD40 Ligand Is Increased in the Metabolic Syndrome and Modulated by Adiponectin" @default.
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• W2023684680 doi "https://doi.org/10.1210/jc.2007-2491" @default.
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