Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023684805> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2023684805 endingPage "211" @default.
- W2023684805 startingPage "203" @default.
- W2023684805 abstract "We have recently reported that Streptozotocin (STZ) diabetic animals operated for partial pancreatectomy (Px) showed normoglycemic status after the operation as compared to uncontrolled hyperglycemia and even death in the diabetic sham operated animals. In order to study the nesidioblastotic factors that initiate pancreatic regeneration in conditions of acute diabetes, we tested the cytosolic extracts from the regenerating pancreas on their ability to cure STZ diabetes in BALB/c mice. BALB/c mice (n = 45) were rendered diabetic with STZ (200 mg/kg body weight) and randomised into two groups so as to receive either cytosolic extract (CE) or saline (diabetic-sham/DS group) for 21 consecutive days. CE treated animals became euglycemic by day 29 and remained normoglycemic during a 190 day follow-up. DS animals remained hyperglycemic with around 70% mortality following sustained uncontrolled hyperglycemia. Islet neogenesis was observed in the CE treated animals and confirmed by increasing circulating insulin concentrations (8.87 +/- 1.07 vs. 41.47 +/- 3.26 microU/ml, mean +/- SEM), islet area (median values 521.5; day 5 to 16481.9 micron2; at 2 months of normoglycemic status) and subsequent decrement in fasting glucose (321.9 +/- 18.00 mg/dl; day 0 to 96.0 +/- 9.02 mg/dl; day 29). Histological analysis of the pancreas in the CE treated group revealed numerous tiny neo-islets as compared to the larger mature islets in the non-diabetic controls. We have shown that factors obtained from the regenerating pancreas carry the potential to initiate islet neogenesis and normoglycemia in the streptozotocin diabetic animals. Our findings could have important clinical implications in the management of diabetes mellitus." @default.
- W2023684805 created "2016-06-24" @default.
- W2023684805 creator A5015293558 @default.
- W2023684805 creator A5018932329 @default.
- W2023684805 date "1999-12-01" @default.
- W2023684805 modified "2023-09-27" @default.
- W2023684805 title "Modulating experimental diabetes by treatment with cytosolic extract from the regenerating pancreas" @default.
- W2023684805 cites W1965757356 @default.
- W2023684805 cites W1979765669 @default.
- W2023684805 cites W1997010909 @default.
- W2023684805 cites W2007884204 @default.
- W2023684805 cites W2009949768 @default.
- W2023684805 cites W2010506909 @default.
- W2023684805 cites W2019064553 @default.
- W2023684805 cites W2067389522 @default.
- W2023684805 cites W2069633047 @default.
- W2023684805 cites W2074207458 @default.
- W2023684805 cites W2088132836 @default.
- W2023684805 cites W2091952693 @default.
- W2023684805 cites W2106950324 @default.
- W2023684805 cites W2150394604 @default.
- W2023684805 cites W2164204589 @default.
- W2023684805 cites W4236586010 @default.
- W2023684805 cites W4239639031 @default.
- W2023684805 cites W4239840248 @default.
- W2023684805 cites W4253601872 @default.
- W2023684805 doi "https://doi.org/10.1016/s0168-8227(99)00098-4" @default.
- W2023684805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10624786" @default.
- W2023684805 hasPublicationYear "1999" @default.
- W2023684805 type Work @default.
- W2023684805 sameAs 2023684805 @default.
- W2023684805 citedByCount "28" @default.
- W2023684805 countsByYear W20236848052013 @default.
- W2023684805 countsByYear W20236848052014 @default.
- W2023684805 countsByYear W20236848052015 @default.
- W2023684805 countsByYear W20236848052016 @default.
- W2023684805 countsByYear W20236848052018 @default.
- W2023684805 countsByYear W20236848052020 @default.
- W2023684805 crossrefType "journal-article" @default.
- W2023684805 hasAuthorship W2023684805A5015293558 @default.
- W2023684805 hasAuthorship W2023684805A5018932329 @default.
- W2023684805 hasConcept C126322002 @default.
- W2023684805 hasConcept C134018914 @default.
- W2023684805 hasConcept C165220095 @default.
- W2023684805 hasConcept C2777397205 @default.
- W2023684805 hasConcept C2778494859 @default.
- W2023684805 hasConcept C2778764654 @default.
- W2023684805 hasConcept C2779280383 @default.
- W2023684805 hasConcept C2779306644 @default.
- W2023684805 hasConcept C2780093864 @default.
- W2023684805 hasConcept C555293320 @default.
- W2023684805 hasConcept C71924100 @default.
- W2023684805 hasConceptScore W2023684805C126322002 @default.
- W2023684805 hasConceptScore W2023684805C134018914 @default.
- W2023684805 hasConceptScore W2023684805C165220095 @default.
- W2023684805 hasConceptScore W2023684805C2777397205 @default.
- W2023684805 hasConceptScore W2023684805C2778494859 @default.
- W2023684805 hasConceptScore W2023684805C2778764654 @default.
- W2023684805 hasConceptScore W2023684805C2779280383 @default.
- W2023684805 hasConceptScore W2023684805C2779306644 @default.
- W2023684805 hasConceptScore W2023684805C2780093864 @default.
- W2023684805 hasConceptScore W2023684805C555293320 @default.
- W2023684805 hasConceptScore W2023684805C71924100 @default.
- W2023684805 hasIssue "3" @default.
- W2023684805 hasLocation W20236848051 @default.
- W2023684805 hasLocation W20236848052 @default.
- W2023684805 hasOpenAccess W2023684805 @default.
- W2023684805 hasPrimaryLocation W20236848051 @default.
- W2023684805 hasRelatedWork W1982624223 @default.
- W2023684805 hasRelatedWork W1996874443 @default.
- W2023684805 hasRelatedWork W2003485540 @default.
- W2023684805 hasRelatedWork W2017797235 @default.
- W2023684805 hasRelatedWork W2023684805 @default.
- W2023684805 hasRelatedWork W2028699422 @default.
- W2023684805 hasRelatedWork W2079112323 @default.
- W2023684805 hasRelatedWork W2084878141 @default.
- W2023684805 hasRelatedWork W2106950324 @default.
- W2023684805 hasRelatedWork W4240404135 @default.
- W2023684805 hasVolume "46" @default.
- W2023684805 isParatext "false" @default.
- W2023684805 isRetracted "false" @default.
- W2023684805 magId "2023684805" @default.
- W2023684805 workType "article" @default.