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• W2023686387 abstract "<h3>Background</h3> Neuromyelitis optica (NMO) is the first inflammatory autoimmune demyelinating disease of the central nervous system for which a specific antigenic target has been identified; the marker autoantibody NMO-IgG specifically recognizes the astrocytic water channel aquaporin 4. Current evidence strongly suggests that NMO-IgG may be pathogenic. Since disability accrues incrementally related to attacks, attack prevention with immunosuppressive therapy is the mainstay of preventing disability. <h3>Objective</h3> To evaluate the efficacy and safety of mycophenolate mofetil therapy in NMO spectrum disorders. <h3>Design</h3> Retrospective case series with prospective telephone follow-up. <h3>Setting</h3> Mayo Clinic Health System. <h3>Patients</h3> Twenty-four patients with NMO spectrum disorders (7 treatment-naive). <h3>Intervention</h3> Mycophenolate mofetil (median dose of 2000 mg per day). <h3>Main Outcome Measures</h3> Annualized relapse rates and disability (Expanded Disability Status Scale). <h3>Results</h3> At a median follow-up of 28 months (range, 18-89 months), 19 patients (79%) were continuing treatment. The median duration of treatment was 27 months (range, 1-89 months). The median annualized posttreatment relapse rate was lower than the pretreatment rate (0.09; range, 0-1.5; and 1.3; range, 0.23-11.8, respectively;<i>P</i> < .001). Disability stabilized or decreased in 22 of 24 patients (91%). One patient died of disease complications during follow-up. Six patients (25%) noted adverse effects during treatment with mycophenolate. <h3>Conclusion</h3> Mycophenolate is associated with reduction in relapse frequency and stable or reduced disability in patients with NMO spectrum disorders." @default.
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• W2023686387 date "2009-09-01" @default.
• W2023686387 modified "2023-10-11" @default.
• W2023686387 title "Treatment of Neuromyelitis Optica With Mycophenolate Mofetil" @default.
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• W2023686387 doi "https://doi.org/10.1001/archneurol.2009.175" @default.
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