FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023687180> ?p ?o ?g. }

• W2023687180 endingPage "1010" @default.
• W2023687180 startingPage "1001" @default.
• W2023687180 abstract "Summary Background Tachykinins‐like substance P (SP) have been shown to play an important role in initiating and perpetuating airway inflammation. Furthermore, they are supposed to be released into tissues in response to stress. Objective The aim of this study was to investigate the effects of stress alone or in combination with allergic airway inflammation on SP expression in sensory neurons innervating the mouse airways. Methods Balb/c mice were systemically sensitized to ovalbumin (OVA), followed by allergen aerosol exposure, and compared with non‐sensitized controls. Additionally, OVA‐sensitized and ‐challenged and non‐sensitized mice were exposed to sound stress. SP expression in airway‐specific and overall vagal sensory neurons of the jugular and nodose ganglion complex was analysed using retrograde neuronal tracing in combination with immunohistochemistry. Preprotachykinin A (PPT‐A) mRNA, the precursor for SP, was quantified in lung tissue by real‐time PCR. Bronchoalveolar lavage (BAL) fluid was obtained, and cell numbers and differentiation were determined. Results Stress and/or allergic airway inflammation significantly increased SP expression in retrograde‐labelled vagal sensory neurons from the mouse lower airways compared with controls [stress: 15.7±0.8% (% of retrograde‐labelled neurons, mean±SEM); allergen: 17.9±0.4%; allergen/stress: 13.1±0.7% vs. controls: 6.3±0.3%]. Similarly, SP expression increased in overall vagal sensory neurons identified by the neuronal marker protein gene product (PGP) 9.5 [stress: 9.3±0.6% (% of PGP 9.5‐positive neurons, means±SEM); allergen: 12.5±0.4%; allergen/stress: 10.2±0.4% vs. controls: 5.1±0.3%]. Furthermore, stress significantly increased PPT‐A mRNA expression in lung tissue from OVA‐sensitized and ‐challenged animals, and immune cells were identified as an additional source of SP in the lung by immunohistochemistry. Associated with enhanced neuronal SP expression, a significantly higher number of leucocytes were found in the BAL following allergen exposure. Further, stress significantly increased allergen‐induced airway inflammation identified by increased leucocyte numbers in BAL fluids. Conclusion The central event of sound stress leads to the stimulation of SP expression in airway‐specific neurons. However, in sensitized stressed mice an additional local source of SP (probably inflammatory cells) might enhance allergic airway inflammation." @default.
• W2023687180 created "2016-06-24" @default.
• W2023687180 creator A5001584134 @default.
• W2023687180 creator A5011126609 @default.
• W2023687180 creator A5038333912 @default.
• W2023687180 creator A5043758621 @default.
• W2023687180 creator A5044154662 @default.
• W2023687180 creator A5047633664 @default.
• W2023687180 creator A5070824120 @default.
• W2023687180 creator A5078545596 @default.
• W2023687180 creator A5079434372 @default.
• W2023687180 date "2006-07-04" @default.
• W2023687180 modified "2023-10-17" @default.
• W2023687180 title "Stress induces substance P in vagal sensory neurons innervating the mouse airways" @default.
• W2023687180 cites W1510130879 @default.
• W2023687180 cites W1648974646 @default.
• W2023687180 cites W1808476113 @default.
• W2023687180 cites W1833471367 @default.
• W2023687180 cites W1965298978 @default.
• W2023687180 cites W1966820993 @default.
• W2023687180 cites W1969606337 @default.
• W2023687180 cites W1976221444 @default.
• W2023687180 cites W1981673655 @default.
• W2023687180 cites W1983691372 @default.
• W2023687180 cites W1986753462 @default.
• W2023687180 cites W1986851215 @default.
• W2023687180 cites W2003100003 @default.
• W2023687180 cites W2003107037 @default.
• W2023687180 cites W2003284232 @default.
• W2023687180 cites W2006923280 @default.
• W2023687180 cites W2007698726 @default.
• W2023687180 cites W2014195246 @default.
• W2023687180 cites W2017907021 @default.
• W2023687180 cites W2018417692 @default.
• W2023687180 cites W2019562281 @default.
• W2023687180 cites W2025707536 @default.
• W2023687180 cites W2030708724 @default.
• W2023687180 cites W2033602195 @default.
• W2023687180 cites W2035651901 @default.
• W2023687180 cites W2042727575 @default.
• W2023687180 cites W2047920764 @default.
• W2023687180 cites W2048032185 @default.
• W2023687180 cites W2050158026 @default.
• W2023687180 cites W2053048914 @default.
• W2023687180 cites W2071599436 @default.
• W2023687180 cites W2073463324 @default.
• W2023687180 cites W2083327761 @default.
• W2023687180 cites W2087894822 @default.
• W2023687180 cites W2091921019 @default.
• W2023687180 cites W2096381182 @default.
• W2023687180 cites W2111064627 @default.
• W2023687180 cites W2114543298 @default.
• W2023687180 cites W2118555287 @default.
• W2023687180 cites W2119614430 @default.
• W2023687180 cites W2136349426 @default.
• W2023687180 cites W2144105896 @default.
• W2023687180 cites W2155514562 @default.
• W2023687180 cites W2181658360 @default.
• W2023687180 cites W2470731951 @default.
• W2023687180 cites W4235634959 @default.
• W2023687180 doi "https://doi.org/10.1111/j.1365-2222.2006.02533.x" @default.
• W2023687180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16911356" @default.
• W2023687180 hasPublicationYear "2006" @default.
• W2023687180 type Work @default.
• W2023687180 sameAs 2023687180 @default.
• W2023687180 citedByCount "30" @default.
• W2023687180 countsByYear W20236871802012 @default.
• W2023687180 countsByYear W20236871802013 @default.
• W2023687180 countsByYear W20236871802016 @default.
• W2023687180 countsByYear W20236871802017 @default.
• W2023687180 countsByYear W20236871802018 @default.
• W2023687180 countsByYear W20236871802021 @default.
• W2023687180 countsByYear W20236871802023 @default.
• W2023687180 crossrefType "journal-article" @default.
• W2023687180 hasAuthorship W2023687180A5001584134 @default.
• W2023687180 hasAuthorship W2023687180A5011126609 @default.
• W2023687180 hasAuthorship W2023687180A5038333912 @default.
• W2023687180 hasAuthorship W2023687180A5043758621 @default.
• W2023687180 hasAuthorship W2023687180A5044154662 @default.
• W2023687180 hasAuthorship W2023687180A5047633664 @default.
• W2023687180 hasAuthorship W2023687180A5070824120 @default.
• W2023687180 hasAuthorship W2023687180A5078545596 @default.
• W2023687180 hasAuthorship W2023687180A5079434372 @default.
• W2023687180 hasConcept C118303440 @default.
• W2023687180 hasConcept C126322002 @default.
• W2023687180 hasConcept C134018914 @default.
• W2023687180 hasConcept C142724271 @default.
• W2023687180 hasConcept C170493617 @default.
• W2023687180 hasConcept C203014093 @default.
• W2023687180 hasConcept C204232928 @default.
• W2023687180 hasConcept C207480886 @default.
• W2023687180 hasConcept C24998067 @default.
• W2023687180 hasConcept C2776378061 @default.
• W2023687180 hasConcept C2776533618 @default.
• W2023687180 hasConcept C2776946954 @default.
• W2023687180 hasConcept C2777714996 @default.
• W2023687180 hasConcept C2777961210 @default.
• W2023687180 hasConcept C2780510475 @default.

• next