Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023687572> ?p ?o ?g. }
- W2023687572 endingPage "169" @default.
- W2023687572 startingPage "159" @default.
- W2023687572 abstract "Serum response factor (SRF) regulates transcription of many serum-inducible and muscle-specific genes. Using a functional screen, we identified LIM kinase-1 as a potent activator of SRF. We show that SRF activation by LIM kinase-1 is dependent on its ability to regulate actin treadmilling. LIM kinase activity is not essential for SRF activation by serum, but signals depend on alterations in actin dynamics. Studies with actin-binding drugs, the actin-specific C2 toxin, and actin overexpression demonstrate that G-actin level controls SRF. Regulation of actin dynamics is necessary for serum induction of a subset of SRF target genes, including vinculin, cytoskeletal actin, and srf itself, and also suffices for their activation. Actin treadmilling provides a convergence point for both serum- and LIM kinase-1-induced signaling to SRF." @default.
- W2023687572 created "2016-06-24" @default.
- W2023687572 creator A5022905294 @default.
- W2023687572 creator A5057335662 @default.
- W2023687572 creator A5067775960 @default.
- W2023687572 creator A5079808383 @default.
- W2023687572 date "1999-07-01" @default.
- W2023687572 modified "2023-10-11" @default.
- W2023687572 title "Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics" @default.
- W2023687572 cites W106434760 @default.
- W2023687572 cites W1484094963 @default.
- W2023687572 cites W1487499673 @default.
- W2023687572 cites W1539711621 @default.
- W2023687572 cites W1560179018 @default.
- W2023687572 cites W1640813462 @default.
- W2023687572 cites W1652393711 @default.
- W2023687572 cites W1964472431 @default.
- W2023687572 cites W1971876716 @default.
- W2023687572 cites W1973844181 @default.
- W2023687572 cites W1975544799 @default.
- W2023687572 cites W1976686277 @default.
- W2023687572 cites W1983438549 @default.
- W2023687572 cites W1984210761 @default.
- W2023687572 cites W198477152 @default.
- W2023687572 cites W1991987237 @default.
- W2023687572 cites W1995617887 @default.
- W2023687572 cites W1996068610 @default.
- W2023687572 cites W1997805342 @default.
- W2023687572 cites W1998847207 @default.
- W2023687572 cites W2002161597 @default.
- W2023687572 cites W2009606782 @default.
- W2023687572 cites W2014411191 @default.
- W2023687572 cites W2027547668 @default.
- W2023687572 cites W2051366705 @default.
- W2023687572 cites W2052219197 @default.
- W2023687572 cites W2053257956 @default.
- W2023687572 cites W2057202215 @default.
- W2023687572 cites W2059534940 @default.
- W2023687572 cites W2072608047 @default.
- W2023687572 cites W2077792958 @default.
- W2023687572 cites W2082148108 @default.
- W2023687572 cites W2085115632 @default.
- W2023687572 cites W2087220458 @default.
- W2023687572 cites W2095910272 @default.
- W2023687572 cites W2104980653 @default.
- W2023687572 cites W2107625881 @default.
- W2023687572 cites W2107688352 @default.
- W2023687572 cites W2109145995 @default.
- W2023687572 cites W2113395636 @default.
- W2023687572 cites W2124754800 @default.
- W2023687572 cites W2130172628 @default.
- W2023687572 cites W2131968097 @default.
- W2023687572 cites W2133424481 @default.
- W2023687572 cites W2143805521 @default.
- W2023687572 cites W2146235041 @default.
- W2023687572 cites W2147927258 @default.
- W2023687572 cites W2152462023 @default.
- W2023687572 cites W2155583879 @default.
- W2023687572 cites W2170906235 @default.
- W2023687572 cites W2312394405 @default.
- W2023687572 cites W24759224 @default.
- W2023687572 doi "https://doi.org/10.1016/s0092-8674(00)81011-9" @default.
- W2023687572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10428028" @default.
- W2023687572 hasPublicationYear "1999" @default.
- W2023687572 type Work @default.
- W2023687572 sameAs 2023687572 @default.
- W2023687572 citedByCount "624" @default.
- W2023687572 countsByYear W20236875722012 @default.
- W2023687572 countsByYear W20236875722013 @default.
- W2023687572 countsByYear W20236875722014 @default.
- W2023687572 countsByYear W20236875722015 @default.
- W2023687572 countsByYear W20236875722016 @default.
- W2023687572 countsByYear W20236875722017 @default.
- W2023687572 countsByYear W20236875722018 @default.
- W2023687572 countsByYear W20236875722019 @default.
- W2023687572 countsByYear W20236875722020 @default.
- W2023687572 countsByYear W20236875722021 @default.
- W2023687572 countsByYear W20236875722022 @default.
- W2023687572 countsByYear W20236875722023 @default.
- W2023687572 crossrefType "journal-article" @default.
- W2023687572 hasAuthorship W2023687572A5022905294 @default.
- W2023687572 hasAuthorship W2023687572A5057335662 @default.
- W2023687572 hasAuthorship W2023687572A5067775960 @default.
- W2023687572 hasAuthorship W2023687572A5079808383 @default.
- W2023687572 hasBestOaLocation W20236875721 @default.
- W2023687572 hasConcept C104317684 @default.
- W2023687572 hasConcept C125705527 @default.
- W2023687572 hasConcept C130861313 @default.
- W2023687572 hasConcept C133702464 @default.
- W2023687572 hasConcept C142669718 @default.
- W2023687572 hasConcept C1491633281 @default.
- W2023687572 hasConcept C153911025 @default.
- W2023687572 hasConcept C189040839 @default.
- W2023687572 hasConcept C205309164 @default.
- W2023687572 hasConcept C2910670019 @default.
- W2023687572 hasConcept C2993400109 @default.
- W2023687572 hasConcept C3620293 @default.
- W2023687572 hasConcept C55493867 @default.