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• W2023689190 abstract "The human immune defense system is composed of two distinct elements: innate immunity located primarily at body surfaces restricted by species-specific CD1 molecules and acquired immunity found mainly in internal compartments associated with individually restricted MHC molecules. Historically, effective vaccines have focused on eliciting pathogen epitope-specific acquired immune responses to protect against infectious diseases; however, such traditional approaches to developing HIV vaccines have been unsuccessful. This review addresses the importance of activating host species-restricted innate immunity to enhance the virus epitope-specific acquired immunity that is needed for HIV vaccines." @default.
• W2023689190 created "2016-06-24" @default.
• W2023689190 creator A5040132448 @default.
• W2023689190 date "2010-05-01" @default.
• W2023689190 modified "2023-09-25" @default.
• W2023689190 title "Species-specific CD1-restricted innate immunity for the development of HIV vaccine" @default.
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• W2023689190 doi "https://doi.org/10.1016/j.vaccine.2009.07.086" @default.
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