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• W2023689359 endingPage "1274" @default.
• W2023689359 startingPage "1267" @default.
• W2023689359 abstract "Isoguanosine (iG) and isocytidine (iC) differ from guanosine (G) and cytidine (C), respectively, in that the amino and carbonyl groups are transposed. The thermodynamic properties of a set of iG, iC containing RNA duplexes have been measured by UV optical melting. It is found that iG-iC replacements usually stabilize duplexes, and the stabilization per iG-iC pair is sequence-dependent. The sequence dependence can be fit to a nearest-neighbor model in which the stabilities of iG--iC pairs depend on the adjacent iG--iC or G--C pairs. For 5'-CG-3'/3'-GC-5' and 5'-GG-3'/3'-CC-5' nearest neighbors, the free energy differences upon iG-iC replacement are smaller than 0.2 kcal/mol at 37 degrees C, regardless of the number of replacements. For 5'-GC-3'/3'-CG-5', however, each iG--iC replacement adds 0.6 kcal/mol stabilizing free energy at 37 degrees C. Stacking propensities of iG and iC as unpaired nucleotides at the end of a duplex are similar to those of G and C. An NMR structure is reported for r(CiGCGiCG)(2) and found to belong to the A-form family. The structure has substantial deviations from standard A-form but is similar to published NMR and/or crystal structures for r(CGCGCG)(2) and 2'-O-methyl (CGCGCG)(2). These results provide benchmarks for theoretical calculations aimed at understanding the fundamental physical basis for the thermodynamic stabilities of nucleic acid duplexes." @default.
• W2023689359 created "2016-06-24" @default.
• W2023689359 creator A5013801926 @default.
• W2023689359 creator A5062097440 @default.
• W2023689359 creator A5078966154 @default.
• W2023689359 date "2001-01-27" @default.
• W2023689359 modified "2023-10-16" @default.
• W2023689359 title "Stability and Structure of RNA Duplexes Containing Isoguanosine and Isocytidine" @default.
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• W2023689359 doi "https://doi.org/10.1021/ja002623i" @default.
• W2023689359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11456697" @default.
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