FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023690211> ?p ?o ?g. }

• W2023690211 endingPage "206" @default.
• W2023690211 startingPage "199" @default.
• W2023690211 abstract "Abstract The present study was carried out to determine if an insulin‐like growth factor (IGF) type activity might be produced by embryonal carcinoma‐derived cells. The cell line used to condition growth medium for the isolation of secreted growth factors was a newly established Dif 5 cell type. Dif 5 cells are a differentiated endoderm‐like cell type derived from F9 embryonal carcinoma cells (which possess properties similar to mouse embryonic stem cells) following extensive exposure to retinoic acid. When growth medium conditioned by Dif 5 cells is chromatographed on Sephadex G‐75 in 1 M acetic acid two peaks of activity are observed which compete for specific [ 125 I]iodo multiplication stimulating activity (MSA) binding to PYS cells. MSA is the rat homologue of human IGF‐II. The high molecular weight fraction (Mr ˜ 60K) apparently corresponds to IGF‐binding protein as determined by its ability to bind [ 125 I]iodo‐MSA. The low molecular weight fraction (Mr ˜ 8K) is biologically active as this fraction stimulates [ 3 H]thymidine incorporation into serum‐starved chick embryo fibroblasts. Radioimmunoassay data indicate that the IGF‐like activity produced by Dif 5 cells is more closely related to IGF‐II than to IGF‐I. Undifferentiated embryonal carcinoma stem cell lines (F9, Nulli, and PCC4) produced little of this MSA‐like activity, while PYS‐2 (parietal endoderm‐like) cells produced about 16 ng MSA/10 6 cells/24 hr as determined by radioimmunoassay. Dif 5 and PSA‐5E (visceral endoderm‐like) cells, are found to secrete significant amounts of MSA into the growth medium (30–50 ng MSA/10 6 cells/24 hr). These findings offer further support to a proposal that MSA (IGF‐II) produced by endoderm cells, particularly visceral endoderm, may serve as an early embryonic growth factor." @default.
• W2023690211 created "2016-06-24" @default.
• W2023690211 creator A5007501845 @default.
• W2023690211 creator A5041111465 @default.
• W2023690211 creator A5077900290 @default.
• W2023690211 creator A5080292274 @default.
• W2023690211 creator A5084959996 @default.
• W2023690211 date "1985-08-01" @default.
• W2023690211 modified "2023-10-16" @default.
• W2023690211 title "Production of insulin-like growth factor-II (MSA) by endoderm-like cells derived from embryonal carcinoma cells: Possible mediator of embryonic cell growth" @default.
• W2023690211 cites W14648726 @default.
• W2023690211 cites W1494815324 @default.
• W2023690211 cites W1594575060 @default.
• W2023690211 cites W1964116721 @default.
• W2023690211 cites W1975639649 @default.
• W2023690211 cites W1976420898 @default.
• W2023690211 cites W1977000145 @default.
• W2023690211 cites W1978858094 @default.
• W2023690211 cites W2001814939 @default.
• W2023690211 cites W2003932465 @default.
• W2023690211 cites W2008115139 @default.
• W2023690211 cites W2012090210 @default.
• W2023690211 cites W2014493428 @default.
• W2023690211 cites W2033728462 @default.
• W2023690211 cites W2033912053 @default.
• W2023690211 cites W2034308453 @default.
• W2023690211 cites W2035109288 @default.
• W2023690211 cites W2036047053 @default.
• W2023690211 cites W2044917338 @default.
• W2023690211 cites W2044936649 @default.
• W2023690211 cites W2065644299 @default.
• W2023690211 cites W2069196243 @default.
• W2023690211 cites W2070547356 @default.
• W2023690211 cites W2072159062 @default.
• W2023690211 cites W2125632609 @default.
• W2023690211 cites W2148106160 @default.
• W2023690211 cites W2161992824 @default.
• W2023690211 cites W2299485510 @default.
• W2023690211 cites W2332605395 @default.
• W2023690211 cites W2897833132 @default.
• W2023690211 cites W4293247451 @default.
• W2023690211 doi "https://doi.org/10.1002/jcp.1041240205" @default.
• W2023690211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4044654" @default.
• W2023690211 hasPublicationYear "1985" @default.
• W2023690211 type Work @default.
• W2023690211 sameAs 2023690211 @default.
• W2023690211 citedByCount "37" @default.
• W2023690211 crossrefType "journal-article" @default.
• W2023690211 hasAuthorship W2023690211A5007501845 @default.
• W2023690211 hasAuthorship W2023690211A5041111465 @default.
• W2023690211 hasAuthorship W2023690211A5077900290 @default.
• W2023690211 hasAuthorship W2023690211A5080292274 @default.
• W2023690211 hasAuthorship W2023690211A5084959996 @default.
• W2023690211 hasConcept C104317684 @default.
• W2023690211 hasConcept C126322002 @default.
• W2023690211 hasConcept C134018914 @default.
• W2023690211 hasConcept C145103041 @default.
• W2023690211 hasConcept C148738053 @default.
• W2023690211 hasConcept C153911025 @default.
• W2023690211 hasConcept C170493617 @default.
• W2023690211 hasConcept C176685330 @default.
• W2023690211 hasConcept C20875687 @default.
• W2023690211 hasConcept C26805974 @default.
• W2023690211 hasConcept C2775960820 @default.
• W2023690211 hasConcept C2777164004 @default.
• W2023690211 hasConcept C2780327976 @default.
• W2023690211 hasConcept C2781121885 @default.
• W2023690211 hasConcept C54355233 @default.
• W2023690211 hasConcept C55493867 @default.
• W2023690211 hasConcept C71924100 @default.
• W2023690211 hasConcept C81885089 @default.
• W2023690211 hasConcept C86803240 @default.
• W2023690211 hasConcept C95444343 @default.
• W2023690211 hasConceptScore W2023690211C104317684 @default.
• W2023690211 hasConceptScore W2023690211C126322002 @default.
• W2023690211 hasConceptScore W2023690211C134018914 @default.
• W2023690211 hasConceptScore W2023690211C145103041 @default.
• W2023690211 hasConceptScore W2023690211C148738053 @default.
• W2023690211 hasConceptScore W2023690211C153911025 @default.
• W2023690211 hasConceptScore W2023690211C170493617 @default.
• W2023690211 hasConceptScore W2023690211C176685330 @default.
• W2023690211 hasConceptScore W2023690211C20875687 @default.
• W2023690211 hasConceptScore W2023690211C26805974 @default.
• W2023690211 hasConceptScore W2023690211C2775960820 @default.
• W2023690211 hasConceptScore W2023690211C2777164004 @default.
• W2023690211 hasConceptScore W2023690211C2780327976 @default.
• W2023690211 hasConceptScore W2023690211C2781121885 @default.
• W2023690211 hasConceptScore W2023690211C54355233 @default.
• W2023690211 hasConceptScore W2023690211C55493867 @default.
• W2023690211 hasConceptScore W2023690211C71924100 @default.
• W2023690211 hasConceptScore W2023690211C81885089 @default.
• W2023690211 hasConceptScore W2023690211C86803240 @default.
• W2023690211 hasConceptScore W2023690211C95444343 @default.
• W2023690211 hasIssue "2" @default.
• W2023690211 hasLocation W20236902111 @default.
• W2023690211 hasLocation W20236902112 @default.
• W2023690211 hasOpenAccess W2023690211 @default.
• W2023690211 hasPrimaryLocation W20236902111 @default.

• next