Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023691883> ?p ?o ?g. }
- W2023691883 endingPage "920" @default.
- W2023691883 startingPage "910" @default.
- W2023691883 abstract "Several in vitro and in vivo studies have suggested that carnosine (β-alanil-l-histidine) and homocarnosine (β-aminobutyril-l-histidine) can act as scavengers of reactive oxygen species. β-Cyclodextrin was functionalized with homocarnosine, obtaining the following new bioconjugate isomers: 6A-[(4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}-4-oxobutyl)amino]-6A-deoxy-β-cyclodextrin and (2AS,3AR)-3A-[(4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}-4-oxobutyl)amino]-3A-deoxy-β-cyclodextrin. Pulse radiolysis investigations show that the β-cyclodextrin homocarnosine bioconjugates are scavengers of OH radicals because of the formation of stable imidazole-centered radicals and the scavenger ability of glucose molecules of the macrocycle. The ability of these new β-cyclodextrin derivatives to inhibit the copper(II) driven LDL oxidation was determined in comparison with that displayed by the analogous carnosine derivatives. Both the β-cyclodextrin carnosine isomers show a higher protective effect than that of free dipeptide and homocarnosine derivatives, bringing into light the role of the β-CD cavity. The ability of these new β-cyclodextrin derivatives to inhibit the copper(II) driven LDL oxidation was determined in comparison with that displayed by the analogous carnosine derivatives. Both the β-cyclodextrin carnosine isomers show a higher protective effect than that of free dipeptide and homocarnosine derivatives, bringing into light the role of the β-CD cavity." @default.
- W2023691883 created "2016-06-24" @default.
- W2023691883 creator A5007788517 @default.
- W2023691883 creator A5009190426 @default.
- W2023691883 creator A5014629487 @default.
- W2023691883 creator A5041922182 @default.
- W2023691883 creator A5050818579 @default.
- W2023691883 creator A5052915971 @default.
- W2023691883 creator A5069384526 @default.
- W2023691883 creator A5070438968 @default.
- W2023691883 creator A5077540699 @default.
- W2023691883 creator A5090877239 @default.
- W2023691883 date "2007-07-01" @default.
- W2023691883 modified "2023-10-03" @default.
- W2023691883 title "Synthesis and antioxidant activity of new homocarnosine β-cyclodextrin conjugates" @default.
- W2023691883 cites W1895664041 @default.
- W2023691883 cites W1926950498 @default.
- W2023691883 cites W1977825117 @default.
- W2023691883 cites W1979609175 @default.
- W2023691883 cites W1987613539 @default.
- W2023691883 cites W1990721326 @default.
- W2023691883 cites W1991676376 @default.
- W2023691883 cites W1997832581 @default.
- W2023691883 cites W2000536632 @default.
- W2023691883 cites W2004694914 @default.
- W2023691883 cites W2005090624 @default.
- W2023691883 cites W2009095670 @default.
- W2023691883 cites W2010281251 @default.
- W2023691883 cites W2011503087 @default.
- W2023691883 cites W2014758223 @default.
- W2023691883 cites W2015290046 @default.
- W2023691883 cites W2022061456 @default.
- W2023691883 cites W2025002404 @default.
- W2023691883 cites W2031201404 @default.
- W2023691883 cites W2037110297 @default.
- W2023691883 cites W2043973087 @default.
- W2023691883 cites W2045579931 @default.
- W2023691883 cites W2050573887 @default.
- W2023691883 cites W2054335668 @default.
- W2023691883 cites W2058490782 @default.
- W2023691883 cites W2058877965 @default.
- W2023691883 cites W2060299184 @default.
- W2023691883 cites W2060898986 @default.
- W2023691883 cites W2066955246 @default.
- W2023691883 cites W2072545005 @default.
- W2023691883 cites W2078070842 @default.
- W2023691883 cites W2081883056 @default.
- W2023691883 cites W2083259778 @default.
- W2023691883 cites W2083811444 @default.
- W2023691883 cites W2087663116 @default.
- W2023691883 cites W2087672347 @default.
- W2023691883 cites W2099167252 @default.
- W2023691883 cites W2105108972 @default.
- W2023691883 cites W2115720141 @default.
- W2023691883 cites W2128726781 @default.
- W2023691883 cites W2133414832 @default.
- W2023691883 cites W2140797812 @default.
- W2023691883 cites W2144837474 @default.
- W2023691883 cites W2158129487 @default.
- W2023691883 cites W2167165600 @default.
- W2023691883 cites W2167719927 @default.
- W2023691883 cites W2170565523 @default.
- W2023691883 cites W2086869672 @default.
- W2023691883 doi "https://doi.org/10.1016/j.ejmech.2006.12.036" @default.
- W2023691883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17336428" @default.
- W2023691883 hasPublicationYear "2007" @default.
- W2023691883 type Work @default.
- W2023691883 sameAs 2023691883 @default.
- W2023691883 citedByCount "22" @default.
- W2023691883 countsByYear W20236918832012 @default.
- W2023691883 countsByYear W20236918832013 @default.
- W2023691883 countsByYear W20236918832014 @default.
- W2023691883 countsByYear W20236918832016 @default.
- W2023691883 countsByYear W20236918832018 @default.
- W2023691883 countsByYear W20236918832021 @default.
- W2023691883 countsByYear W20236918832023 @default.
- W2023691883 crossrefType "journal-article" @default.
- W2023691883 hasAuthorship W2023691883A5007788517 @default.
- W2023691883 hasAuthorship W2023691883A5009190426 @default.
- W2023691883 hasAuthorship W2023691883A5014629487 @default.
- W2023691883 hasAuthorship W2023691883A5041922182 @default.
- W2023691883 hasAuthorship W2023691883A5050818579 @default.
- W2023691883 hasAuthorship W2023691883A5052915971 @default.
- W2023691883 hasAuthorship W2023691883A5069384526 @default.
- W2023691883 hasAuthorship W2023691883A5070438968 @default.
- W2023691883 hasAuthorship W2023691883A5077540699 @default.
- W2023691883 hasAuthorship W2023691883A5090877239 @default.
- W2023691883 hasConcept C139066938 @default.
- W2023691883 hasConcept C185592680 @default.
- W2023691883 hasConcept C2777832065 @default.
- W2023691883 hasConcept C2778004101 @default.
- W2023691883 hasConcept C2778460671 @default.
- W2023691883 hasConcept C2779138802 @default.
- W2023691883 hasConcept C2779433975 @default.
- W2023691883 hasConcept C2780687331 @default.
- W2023691883 hasConcept C515207424 @default.
- W2023691883 hasConcept C55493867 @default.
- W2023691883 hasConcept C71240020 @default.