FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023692020> ?p ?o ?g. }

• W2023692020 endingPage "551" @default.
• W2023692020 startingPage "543" @default.
• W2023692020 abstract "Glutamate or a related excitatory amino acid is thought to be the major excitatory neurotransmitter of hippocampal afferents, intrinsic neurons, and efferents. We have used an autoradiographic technique to investigate the status of excitatory amino acid receptors in the hippocampal formation of patients dying with dementia of the Alzheimer type (DAT). We examined L-[3H]glutamate binding to sections from the hippocampal formation of six patients dying of DAT and six patients without DAT and found marked reductions in total [3H]glutamate binding in all regions of hippocampus and adjacent parahippocampal cortex in DAT brains as compared to controls. When subtypes of excitatory amino acid receptors were assayed, it was found that binding to the N-methyl-D-aspartate (NMDA)-sensitive receptor was reduced by 75-87%, with the greatest loss found in stratum moleculare and stratum pyramidale of CA1. Binding to quisqualate (QA)-sensitive receptors was reduced by 45-69%. There were smaller reductions (21-46%) in GABAA receptors in DAT cases. Muscarinic cholinergic receptors assayed in adjacent sections of hippocampal formation were unchanged in DAT. Benzodiazepine receptors were reduced significantly only in parahippocampal cortex by 44%. These results suggest that glutamatergic neurotransmission within the hippocampal formation is likely to be severely impaired in Alzheimer's disease. Such impairment may account for some of the cognitive decline and memory deficits that characterize DAT." @default.
• W2023692020 created "2016-06-24" @default.
• W2023692020 creator A5013883887 @default.
• W2023692020 creator A5015548702 @default.
• W2023692020 creator A5019611038 @default.
• W2023692020 creator A5044891578 @default.
• W2023692020 date "1987-02-01" @default.
• W2023692020 modified "2023-10-16" @default.
• W2023692020 title "Dementia of the Alzheimer's Type: Changes in Hippocampal L-[³H]Glutamate Binding" @default.
• W2023692020 cites W1511379621 @default.
• W2023692020 cites W1526592985 @default.
• W2023692020 cites W1637093671 @default.
• W2023692020 cites W1906221302 @default.
• W2023692020 cites W1957209685 @default.
• W2023692020 cites W1963895777 @default.
• W2023692020 cites W1970377013 @default.
• W2023692020 cites W1972614082 @default.
• W2023692020 cites W1984354543 @default.
• W2023692020 cites W1985221567 @default.
• W2023692020 cites W1986398611 @default.
• W2023692020 cites W1987990912 @default.
• W2023692020 cites W1991772445 @default.
• W2023692020 cites W1993877320 @default.
• W2023692020 cites W2008109588 @default.
• W2023692020 cites W2013651799 @default.
• W2023692020 cites W2016649333 @default.
• W2023692020 cites W2020749289 @default.
• W2023692020 cites W2024490746 @default.
• W2023692020 cites W2025801062 @default.
• W2023692020 cites W2033041856 @default.
• W2023692020 cites W2043813981 @default.
• W2023692020 cites W2051119534 @default.
• W2023692020 cites W2055203705 @default.
• W2023692020 cites W2061532372 @default.
• W2023692020 cites W2070455103 @default.
• W2023692020 cites W2077424037 @default.
• W2023692020 cites W2086044085 @default.
• W2023692020 cites W2104642940 @default.
• W2023692020 cites W2107310149 @default.
• W2023692020 cites W2126974689 @default.
• W2023692020 cites W2154584808 @default.
• W2023692020 cites W2156220037 @default.
• W2023692020 cites W2165651695 @default.
• W2023692020 cites W2171405125 @default.
• W2023692020 cites W2180941170 @default.
• W2023692020 doi "https://doi.org/10.1111/j.1471-4159.1987.tb04127.x" @default.
• W2023692020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2878980" @default.
• W2023692020 hasPublicationYear "1987" @default.
• W2023692020 type Work @default.
• W2023692020 sameAs 2023692020 @default.
• W2023692020 citedByCount "273" @default.
• W2023692020 countsByYear W20236920202012 @default.
• W2023692020 countsByYear W20236920202013 @default.
• W2023692020 countsByYear W20236920202014 @default.
• W2023692020 countsByYear W20236920202015 @default.
• W2023692020 countsByYear W20236920202016 @default.
• W2023692020 countsByYear W20236920202017 @default.
• W2023692020 countsByYear W20236920202018 @default.
• W2023692020 countsByYear W20236920202019 @default.
• W2023692020 countsByYear W20236920202020 @default.
• W2023692020 countsByYear W20236920202021 @default.
• W2023692020 countsByYear W20236920202022 @default.
• W2023692020 countsByYear W20236920202023 @default.
• W2023692020 crossrefType "journal-article" @default.
• W2023692020 hasAuthorship W2023692020A5013883887 @default.
• W2023692020 hasAuthorship W2023692020A5015548702 @default.
• W2023692020 hasAuthorship W2023692020A5019611038 @default.
• W2023692020 hasAuthorship W2023692020A5044891578 @default.
• W2023692020 hasBestOaLocation W20236920202 @default.
• W2023692020 hasConcept C112592302 @default.
• W2023692020 hasConcept C126322002 @default.
• W2023692020 hasConcept C134018914 @default.
• W2023692020 hasConcept C148762608 @default.
• W2023692020 hasConcept C169760540 @default.
• W2023692020 hasConcept C170493617 @default.
• W2023692020 hasConcept C185592680 @default.
• W2023692020 hasConcept C2776219046 @default.
• W2023692020 hasConcept C2779134260 @default.
• W2023692020 hasConcept C2780648746 @default.
• W2023692020 hasConcept C2781161787 @default.
• W2023692020 hasConcept C502032728 @default.
• W2023692020 hasConcept C529278444 @default.
• W2023692020 hasConcept C61174792 @default.
• W2023692020 hasConcept C71924100 @default.
• W2023692020 hasConcept C86803240 @default.
• W2023692020 hasConceptScore W2023692020C112592302 @default.
• W2023692020 hasConceptScore W2023692020C126322002 @default.
• W2023692020 hasConceptScore W2023692020C134018914 @default.
• W2023692020 hasConceptScore W2023692020C148762608 @default.
• W2023692020 hasConceptScore W2023692020C169760540 @default.
• W2023692020 hasConceptScore W2023692020C170493617 @default.
• W2023692020 hasConceptScore W2023692020C185592680 @default.
• W2023692020 hasConceptScore W2023692020C2776219046 @default.
• W2023692020 hasConceptScore W2023692020C2779134260 @default.
• W2023692020 hasConceptScore W2023692020C2780648746 @default.
• W2023692020 hasConceptScore W2023692020C2781161787 @default.
• W2023692020 hasConceptScore W2023692020C502032728 @default.
• W2023692020 hasConceptScore W2023692020C529278444 @default.

• next