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- W2023693584 abstract "<h2>Abstract</h2> Using the scanning electron microscope, topographic changes occurring in experimental strangulation obstruction have been investigated. Control specimens revealed broad, tongue-shaped villi on the mucosal surface, but morphologic changes after only three hours of strangulation obstruction were obscured by extravasated erythrocytes and cellular debris which covered the normal mucosal surface. The normal serosal surface was irregular and contained three varieties of previously undescribed pits which ranged from 1 to 12 μ in diameter. Loss of serosal mesothelium began at one hour after strangulation obstruction and was nearly complete after six hours. Only intermediate sized pits were observed in the subserosal layer after one hour, but clefts up to 60 μ in diameter appeared by three hours. These serosal defects filled with erythrocytes at six hours, and the bowel wall became covered with a coagulum by nine hours. The coagulum persisted up to twenty-four hours, which was the longest time interval for which specimens were examined. Bacterial toxins and lytic enzymes most probably digest the coagulum seen, allowing intraluminal material to filter through the intestinal wall through the pits and clefts seen in earlier specimens. The discovery of microscopic serosal pits and the observation of a process of early shreading of the bowel wall provide an explanation for the transfer of toxic intraluminal bowel contents into the peritoneal cavity in strangulation obstruction." @default.
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- W2023693584 date "1973-01-01" @default.
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- W2023693584 title "Scanning electron microscopy of small bowel strangulation obstruction" @default.
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- W2023693584 doi "https://doi.org/10.1016/0002-9610(73)90017-2" @default.
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