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- W2023694172 abstract "Expression of interferon-τ gene (IFNT) by conceptuses of cattle and sheep must be in phase with the physiological state of the mother if the pregnancy is to be successful. IFNT has a close-to-consensus AP1 site (−71 to −64), overlapping a binding site for Ets-2 (−79 to −70), the key transcription factor controlling IFNT expression. When a bovine IFNT gene control region-luciferase (luc) construct was transfected into mouse 3T3 fibroblasts in the presence of Ets-2 and oncogenic Ras, luc expression was activated (50- to 100-fold). Mutations in either the activator protein 1 (AP1) site or the Ets-2 site of this construct abolished this effect. Similarly, a mutation of Thr72 of the Ets-2 or the addition of a specific inhibitor for the MAPK signal transduction pathway also markedly reduced expression. IFNT promoter activity was up-regulated in response to colony-stimulating factor-1 in 3T3 cells expressing the colony-stimulating factor-1 receptor c-fms. This response did not occur when the AP1 site or the Ets-..." @default.
- W2023694172 created "2016-06-24" @default.
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- W2023694172 date "2004-10-01" @default.
- W2023694172 modified "2023-10-18" @default.
- W2023694172 title "Regulation of Interferon-τ (IFN-τ) Gene Promoters by Growth Factors that Target the Ets-2 Composite Enhancer: A Possible Model for Maternal Control of IFN-τ Production by the Conceptus during Early Pregnancy" @default.
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- W2023694172 doi "https://doi.org/10.1210/en.2004-0606" @default.
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