Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023694220> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2023694220 endingPage "46" @default.
- W2023694220 startingPage "42" @default.
- W2023694220 abstract "Gaucher disease (GD) is characterized by clinical heterogeneity and is associated with metabolic abnormalities such as increased resting energy expenditure.To assess the basal metabolic rate (BMR) of patients with GD type I followed at the Gaucher Disease Reference Center of Rio Grande do Sul, Brazil.Fourteen patients (male=6) and 14 healthy controls matched by gender, age and body mass index (BMI) were included in the study. The nutritional status of patients was assessed by BMI. The BMR was measured by indirect calorimetry. In two patients, it was possible to perform BMR in the pre- and the post-treatment periods.Mean age and BMI of patients and controls were, respectively, 32.8 ± 17.6 and 32.1 ± 16.6 years and 23.3 ± 3.1 and 22.4 ± 3.1 kg/m(2). Twelve patients were receiving enzyme replacement therapy (ERT) with imiglucerase (mean duration of treatment=5.2 ± 4.3 years; mean dosage of imiglucerase=24.2 ± 7.3 UI/kg/inf). Five patients (36%) were overweight, and nine (64%) were normal weight. Mean BMR of patients on ERT was 27.1% higher than that of controls (p=0.007). There was no difference between the BMR of patients on ERT and not on ERT (n=4) (p=0.92). Comparing the BMR of patients on ERT and their controls with the BMR estimated by the Harris-Benedict equation, the BMR of patients was 6.3% higher than the estimated (p = 0.1), while the BMR of their controls was 17.0% lower than the estimated (p = 0.001).Most treated GD type I patients were normal weight. The patients including those on ERT showed higher BMR when compared to controls. Imiglucerase is probably unable to normalize the hypermetabolism presented by GD type I patients. Additional studies should be performed to confirm our findings." @default.
- W2023694220 created "2016-06-24" @default.
- W2023694220 creator A5021968370 @default.
- W2023694220 creator A5037225949 @default.
- W2023694220 creator A5041942253 @default.
- W2023694220 creator A5044929823 @default.
- W2023694220 creator A5076050376 @default.
- W2023694220 creator A5083543473 @default.
- W2023694220 date "2011-01-01" @default.
- W2023694220 modified "2023-10-08" @default.
- W2023694220 title "Gaucher disease type I: Assessment of basal metabolic rate in patients from southern Brazil" @default.
- W2023694220 cites W2011606380 @default.
- W2023694220 cites W2031608061 @default.
- W2023694220 cites W2041811148 @default.
- W2023694220 cites W2055100951 @default.
- W2023694220 cites W2060440668 @default.
- W2023694220 cites W2077868231 @default.
- W2023694220 cites W2088522082 @default.
- W2023694220 cites W2102755525 @default.
- W2023694220 cites W2103680156 @default.
- W2023694220 cites W2107072844 @default.
- W2023694220 cites W2114362599 @default.
- W2023694220 cites W2120868701 @default.
- W2023694220 cites W2125650673 @default.
- W2023694220 cites W2168077471 @default.
- W2023694220 cites W2168507439 @default.
- W2023694220 cites W4237631630 @default.
- W2023694220 cites W4242472906 @default.
- W2023694220 cites W4255185979 @default.
- W2023694220 doi "https://doi.org/10.1016/j.bcmd.2010.10.008" @default.
- W2023694220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21075022" @default.
- W2023694220 hasPublicationYear "2011" @default.
- W2023694220 type Work @default.
- W2023694220 sameAs 2023694220 @default.
- W2023694220 citedByCount "12" @default.
- W2023694220 countsByYear W20236942202013 @default.
- W2023694220 countsByYear W20236942202015 @default.
- W2023694220 countsByYear W20236942202016 @default.
- W2023694220 countsByYear W20236942202018 @default.
- W2023694220 countsByYear W20236942202019 @default.
- W2023694220 countsByYear W20236942202021 @default.
- W2023694220 countsByYear W20236942202022 @default.
- W2023694220 countsByYear W20236942202023 @default.
- W2023694220 crossrefType "journal-article" @default.
- W2023694220 hasAuthorship W2023694220A5021968370 @default.
- W2023694220 hasAuthorship W2023694220A5037225949 @default.
- W2023694220 hasAuthorship W2023694220A5041942253 @default.
- W2023694220 hasAuthorship W2023694220A5044929823 @default.
- W2023694220 hasAuthorship W2023694220A5076050376 @default.
- W2023694220 hasAuthorship W2023694220A5083543473 @default.
- W2023694220 hasConcept C126322002 @default.
- W2023694220 hasConcept C187212893 @default.
- W2023694220 hasConcept C2778024521 @default.
- W2023694220 hasConcept C2779134260 @default.
- W2023694220 hasConcept C2779306644 @default.
- W2023694220 hasConcept C2779969927 @default.
- W2023694220 hasConcept C2780221984 @default.
- W2023694220 hasConcept C2780586474 @default.
- W2023694220 hasConcept C2988147884 @default.
- W2023694220 hasConcept C71924100 @default.
- W2023694220 hasConcept C82736064 @default.
- W2023694220 hasConcept C90924648 @default.
- W2023694220 hasConceptScore W2023694220C126322002 @default.
- W2023694220 hasConceptScore W2023694220C187212893 @default.
- W2023694220 hasConceptScore W2023694220C2778024521 @default.
- W2023694220 hasConceptScore W2023694220C2779134260 @default.
- W2023694220 hasConceptScore W2023694220C2779306644 @default.
- W2023694220 hasConceptScore W2023694220C2779969927 @default.
- W2023694220 hasConceptScore W2023694220C2780221984 @default.
- W2023694220 hasConceptScore W2023694220C2780586474 @default.
- W2023694220 hasConceptScore W2023694220C2988147884 @default.
- W2023694220 hasConceptScore W2023694220C71924100 @default.
- W2023694220 hasConceptScore W2023694220C82736064 @default.
- W2023694220 hasConceptScore W2023694220C90924648 @default.
- W2023694220 hasIssue "1" @default.
- W2023694220 hasLocation W20236942201 @default.
- W2023694220 hasLocation W20236942202 @default.
- W2023694220 hasOpenAccess W2023694220 @default.
- W2023694220 hasPrimaryLocation W20236942201 @default.
- W2023694220 hasRelatedWork W2025505654 @default.
- W2023694220 hasRelatedWork W2080427231 @default.
- W2023694220 hasRelatedWork W2091445450 @default.
- W2023694220 hasRelatedWork W2112281920 @default.
- W2023694220 hasRelatedWork W2158801752 @default.
- W2023694220 hasRelatedWork W2183420343 @default.
- W2023694220 hasRelatedWork W2277667005 @default.
- W2023694220 hasRelatedWork W2400436892 @default.
- W2023694220 hasRelatedWork W2728714751 @default.
- W2023694220 hasRelatedWork W2899091876 @default.
- W2023694220 hasVolume "46" @default.
- W2023694220 isParatext "false" @default.
- W2023694220 isRetracted "false" @default.
- W2023694220 magId "2023694220" @default.
- W2023694220 workType "article" @default.