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- W2023694288 abstract "Feeding and drinking responses to varying subcutaneous doses of short-acting insulin were determined. At a near optimum dose (20 units/kg), augmentation of feeding lasted 3–4 hr. The effect of repeated injections varied with the interval between them: less feeding was elicited by a second injection up to 3 days after the first. A single insulin injection augmented intakes of water, chow pellets, glucose solutions and sweetened or unsweetened milk concentrates. No differences were found between the effects of food deprivation and of injected insulin on intakes of glucose solutions flavoured with saccharine or quinine, even though increases in saccharine-flavoured glucose intake from first to second acquaintance were detectable. Thus, although repeated injection of long-acting insulin elicits sugar appetite, there was no evidence of immediate elicitation of an appetite for sweetened materials. It is postulated that in the rat, as in man, a single insulin injection causes physiological changes which paradoxically elicit a behavioral state similar to that elicited by food deprivation. Insulin augmented the rate of instrumental responding for food in both the fed and the starved rat." @default.
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- W2023694288 date "1968-05-01" @default.
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- W2023694288 title "Hunger elicited in the rat by a single injection of bovine crystalline insulin☆" @default.
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- W2023694288 doi "https://doi.org/10.1016/0031-9384(68)90075-9" @default.
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