FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023694559> ?p ?o ?g. }

• W2023694559 endingPage "429" @default.
• W2023694559 startingPage "417" @default.
• W2023694559 abstract "Of the many approaches to the possible etiology of cancer, it would appear that study of precancerous conditions such as Bowen's disease could be a fruitful one. It is the purpose of this communication to present experimental evidence pointing to a virus etiology of Bowen's disease. A number of observations by the senior author led to the present investigation. Chronic parenchymatous keratitis in rabbits was observed after the injection of filtered serum from a patient with psoriasis, complicated by arthritis and relapsing corneal ulcers (1). However, an abortive form of parenchymatous keratitis resulted when heated sera from other patients with psoriasis were used. Severe orchitis has been produced in rabbits by injection of filtered and unfiltered serum from patients with psoriasis, pemphigus and Duhring's disease. Control injections of normal tissue failed to produce orchitis for eight or nine passages. Subsequently, however, orchitis developed and resulted in death of the animals. Injection of blood from a control animal into the testes of another rabbit also resulted in orchitis and death. These results indicated that an autochthonous virus was the causative agent (2). The chick's embryonated egg lends itself exceptionally well to studies because there is little danger that it may harbor endogenous viruses that could become activated in the course of the experiments. Cottral (3) found five viral and four bacterial diseases in birds which might have transmission. Cox (4), however, pointed out that the chances were rather remote of picking up an endogenous virus in an embryonated egg. Among advantages of the use of embryonated eggs for etiological studies are the absence of complement and antibodies (5, 25, 26, 27), the readiness with which implants take on the allantois, and the susceptibility of the yolk sac to viral and rickettsial infection. The method presents certain disadvantages. A refractory period on the eighteenth and nineteenth day after incubation may interfere with growth (6). Slowly growing tumors may not reach maturity, since the period of development of normal and pathological tissues in a chick membrane is limited to approximately ten days. The optimum site of implantation varies with different diseases. The incubation temperature and the time of sacrifice may influence the results of experiments. Even individual eggs differ in their susceptibility to viral infection. Many eggs, for instance, do not develop lesions of the allantois after inoculation with the variola virus (28)." @default.
• W2023694559 created "2016-06-24" @default.
• W2023694559 creator A5036565123 @default.
• W2023694559 creator A5055076435 @default.
• W2023694559 creator A5074158536 @default.
• W2023694559 date "1954-05-01" @default.
• W2023694559 modified "2023-09-27" @default.
• W2023694559 title "The Response of Embryonic Chick Membrane to Bowen's Intraepithelial Cancer1" @default.
• W2023694559 cites W2004548537 @default.
• W2023694559 cites W2021102926 @default.
• W2023694559 cites W2034388743 @default.
• W2023694559 cites W2034598264 @default.
• W2023694559 cites W2042549315 @default.
• W2023694559 cites W2053767866 @default.
• W2023694559 cites W2090027491 @default.
• W2023694559 cites W2091005485 @default.
• W2023694559 cites W2137834586 @default.
• W2023694559 cites W2141953313 @default.
• W2023694559 cites W2161990313 @default.
• W2023694559 cites W2315263400 @default.
• W2023694559 cites W2335735860 @default.
• W2023694559 doi "https://doi.org/10.1038/jid.1954.58" @default.
• W2023694559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13163505" @default.
• W2023694559 hasPublicationYear "1954" @default.
• W2023694559 type Work @default.
• W2023694559 sameAs 2023694559 @default.
• W2023694559 citedByCount "10" @default.
• W2023694559 countsByYear W20236945592013 @default.
• W2023694559 countsByYear W20236945592015 @default.
• W2023694559 countsByYear W20236945592016 @default.
• W2023694559 crossrefType "journal-article" @default.
• W2023694559 hasAuthorship W2023694559A5036565123 @default.
• W2023694559 hasAuthorship W2023694559A5055076435 @default.
• W2023694559 hasAuthorship W2023694559A5074158536 @default.
• W2023694559 hasBestOaLocation W20236945591 @default.
• W2023694559 hasConcept C104317684 @default.
• W2023694559 hasConcept C126322002 @default.
• W2023694559 hasConcept C145103041 @default.
• W2023694559 hasConcept C185592680 @default.
• W2023694559 hasConcept C2781280921 @default.
• W2023694559 hasConcept C3019992690 @default.
• W2023694559 hasConcept C41625074 @default.
• W2023694559 hasConcept C54355233 @default.
• W2023694559 hasConcept C71924100 @default.
• W2023694559 hasConcept C86803240 @default.
• W2023694559 hasConceptScore W2023694559C104317684 @default.
• W2023694559 hasConceptScore W2023694559C126322002 @default.
• W2023694559 hasConceptScore W2023694559C145103041 @default.
• W2023694559 hasConceptScore W2023694559C185592680 @default.
• W2023694559 hasConceptScore W2023694559C2781280921 @default.
• W2023694559 hasConceptScore W2023694559C3019992690 @default.
• W2023694559 hasConceptScore W2023694559C41625074 @default.
• W2023694559 hasConceptScore W2023694559C54355233 @default.
• W2023694559 hasConceptScore W2023694559C71924100 @default.
• W2023694559 hasConceptScore W2023694559C86803240 @default.
• W2023694559 hasIssue "5" @default.
• W2023694559 hasLocation W20236945591 @default.
• W2023694559 hasLocation W20236945592 @default.
• W2023694559 hasOpenAccess W2023694559 @default.
• W2023694559 hasPrimaryLocation W20236945591 @default.
• W2023694559 hasRelatedWork W1974049468 @default.
• W2023694559 hasRelatedWork W1997627039 @default.
• W2023694559 hasRelatedWork W2069467828 @default.
• W2023694559 hasRelatedWork W2587096119 @default.
• W2023694559 hasRelatedWork W2790748761 @default.
• W2023694559 hasRelatedWork W3015118083 @default.
• W2023694559 hasRelatedWork W3113257437 @default.
• W2023694559 hasRelatedWork W3114471381 @default.
• W2023694559 hasRelatedWork W3144811071 @default.
• W2023694559 hasRelatedWork W4233482089 @default.
• W2023694559 hasVolume "22" @default.
• W2023694559 isParatext "false" @default.
• W2023694559 isRetracted "false" @default.
• W2023694559 magId "2023694559" @default.
• W2023694559 workType "article" @default.