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• W2023696377 abstract "We investigated hepatoprotective activity and antioxidant effect of the 2,5-dihydroxy-4,3′-di(β-d-glucopyranosyloxy)-trans-stilbene that purified from Morus bombycis Koidzumi roots against CCl4-induced liver damage in rats. The 2,5-dihydroxy-4,3′-di(β-d-glucopyranosyloxy)-trans-stilbene displayed dose-dependent superoxide radical scavenging activity (IC50 = 430.2 μg/ml), as assayed by the electron spin resonance (ESR) spin-trapping technique. The increase in aspartate aminotransferase (AST) activities in serum associated with carbon tetrachloride (CCl4)-induced liver injury was inhibited by 2,5-dihydroxy-4,3′-di(β-d-glucopyranosyloxy)-trans-stilbene and at a dose of 400 ∼ 600 mg/kg samples had hepatoprotective activity comparable to the standard agent, silymarin. The biochemical assays were confirmed by histological observations showing that the 2,5-dihydroxy-4,3′-di(β-d-glucopyranosyloxy)-trans-stilbene decreased cell ballooning in response to CCl4 treatment. These results demonstrate that the 2,5-dihydroxy-4,3′-di(β-d-glucopyranosyloxy)-trans-stilbene is a potent antioxidant with a liver protective action against CCl4-induced hepatotoxicity." @default.
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• W2023696377 date "2006-01-01" @default.
• W2023696377 modified "2023-10-12" @default.
• W2023696377 title "Antioxidant effects and hepatoprotective activity of 2,5-dihydroxy-4,3′-di(β-<scp>d</scp>-glucopyranosyloxy)-<i>trans</i>-stilbene from<i>Morus bombycis</i>Koidzumi roots on CCl₄-induced liver damage" @default.
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• W2023696377 doi "https://doi.org/10.1080/10715760600803823" @default.
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