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- W2023702217 abstract "Positive end-expiratory pressure (PEEP) decreases dynamic respiratory system compliance (Crs) in ventilated infants. As dynamic Crs measurements reflect airway resistance, we utilized a pulse method (J. Appl Physiol. 49:1116) to test the effect of PEEP on static Crs. We measured Crs in 11 infants (gestational age 33±4{mean±S.D.}weeks, weight 2052±704 gms, and study age 29±35 days) with respiratory failure supported with a constant flow ventilator. Flow, transrespiratory pressure, and tidal volume were recorded. We calculated pulse Crs by dividing flow by the slope of the linear portion of the pressure tracing. Static and dynamic Crs were measured by standard methods. Values of Crs were compared from PEEPs of 2.5 to 10.0 cms H2O. At the baseline ventilator settings, pulse and static Crs were similar (b=0.94, r2=90%), and both exceeded dynamic Crs (p<0.005). The effect of PEEP is shown below: Comparing individual regression slopes, pulse Crs decreased uniformly among the infants (F=1.80) from PEEPs of 5.0 to 10.0 cms. PEEPs exceeding 5.0 cms may overdistend the lungs and chest wall of ventilated infants as demonstrated by a decrease in pulse Crs." @default.
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- W2023702217 date "1984-04-01" @default.
- W2023702217 modified "2023-09-26" @default.
- W2023702217 title "EFFECT OF POSITIVE END-EXPIRATORY PRESSURE ON PULSE RESPIRATORY COMPLIANCE IN VENTILATED INFANTS" @default.
- W2023702217 doi "https://doi.org/10.1203/00006450-198404001-01890" @default.
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