FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023703027> ?p ?o ?g. }

• W2023703027 endingPage "11742" @default.
• W2023703027 startingPage "11738" @default.
• W2023703027 abstract "In both humans and animals certain individuals seek stimuli or situations that are considered stressful and consequently avoided by others. A common feature of such situations is an activation of the hypothalamo-pituitary-adrenal axis leading to secretion of glucocorticoids. Since glucocorticoids have euphoric effects in some individuals and have been shown to potentiate the reinforcing properties of drugs of abuse in animals, we hypothesized that corticosterone secretion during stress-like situations may have reinforcing effects and that a higher sensitivity to the reinforcing effects of glucocorticoids might be a biological basis of sensation seeking. In this report we show that (i) corticosterone has reinforcing properties, as evidenced by the development of intravenous self-administration, (ii) self-administration of corticosterone is observed at plasma levels that are comparable to those induced by stress, and (iii) there are individual differences in corticosterone self-administration, which are related to individual reactivity to novelty and sensitivity to drugs of abuse, behavioral features akin to certain traits of high-sensation seekers. These findings provide insight into the physiological role of glucocorticoids and the biology of sensation seeking and may have clinical implications." @default.
• W2023703027 created "2016-06-24" @default.
• W2023703027 creator A5006173939 @default.
• W2023703027 creator A5032881505 @default.
• W2023703027 creator A5046905337 @default.
• W2023703027 creator A5051171617 @default.
• W2023703027 creator A5062773752 @default.
• W2023703027 creator A5080791001 @default.
• W2023703027 date "1993-12-15" @default.
• W2023703027 modified "2023-10-10" @default.
• W2023703027 title "Corticosterone in the range of stress-induced levels possesses reinforcing properties: implications for sensation-seeking behaviors." @default.
• W2023703027 cites W1971422535 @default.
• W2023703027 cites W1974348633 @default.
• W2023703027 cites W1978693659 @default.
• W2023703027 cites W1987089574 @default.
• W2023703027 cites W2001865657 @default.
• W2023703027 cites W2008855429 @default.
• W2023703027 cites W2018069791 @default.
• W2023703027 cites W2018514933 @default.
• W2023703027 cites W2028736841 @default.
• W2023703027 cites W2030403057 @default.
• W2023703027 cites W2031288385 @default.
• W2023703027 cites W2032955802 @default.
• W2023703027 cites W2036115706 @default.
• W2023703027 cites W2050052806 @default.
• W2023703027 cites W2050642260 @default.
• W2023703027 cites W2061161259 @default.
• W2023703027 cites W2061344417 @default.
• W2023703027 cites W2067210690 @default.
• W2023703027 cites W2069391731 @default.
• W2023703027 cites W2079679654 @default.
• W2023703027 cites W2104009710 @default.
• W2023703027 cites W2113962949 @default.
• W2023703027 cites W2135117278 @default.
• W2023703027 cites W2163732290 @default.
• W2023703027 cites W2174764226 @default.
• W2023703027 cites W2742265051 @default.
• W2023703027 doi "https://doi.org/10.1073/pnas.90.24.11738" @default.
• W2023703027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/48059" @default.
• W2023703027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8265619" @default.
• W2023703027 hasPublicationYear "1993" @default.
• W2023703027 type Work @default.
• W2023703027 sameAs 2023703027 @default.
• W2023703027 citedByCount "291" @default.
• W2023703027 countsByYear W20237030272012 @default.
• W2023703027 countsByYear W20237030272013 @default.
• W2023703027 countsByYear W20237030272014 @default.
• W2023703027 countsByYear W20237030272015 @default.
• W2023703027 countsByYear W20237030272016 @default.
• W2023703027 countsByYear W20237030272017 @default.
• W2023703027 countsByYear W20237030272018 @default.
• W2023703027 countsByYear W20237030272019 @default.
• W2023703027 countsByYear W20237030272020 @default.
• W2023703027 countsByYear W20237030272021 @default.
• W2023703027 countsByYear W20237030272022 @default.
• W2023703027 countsByYear W20237030272023 @default.
• W2023703027 crossrefType "journal-article" @default.
• W2023703027 hasAuthorship W2023703027A5006173939 @default.
• W2023703027 hasAuthorship W2023703027A5032881505 @default.
• W2023703027 hasAuthorship W2023703027A5046905337 @default.
• W2023703027 hasAuthorship W2023703027A5051171617 @default.
• W2023703027 hasAuthorship W2023703027A5062773752 @default.
• W2023703027 hasAuthorship W2023703027A5080791001 @default.
• W2023703027 hasBestOaLocation W20237030272 @default.
• W2023703027 hasConcept C115816405 @default.
• W2023703027 hasConcept C126322002 @default.
• W2023703027 hasConcept C130093455 @default.
• W2023703027 hasConcept C134018914 @default.
• W2023703027 hasConcept C15744967 @default.
• W2023703027 hasConcept C169760540 @default.
• W2023703027 hasConcept C187288502 @default.
• W2023703027 hasConcept C2778555786 @default.
• W2023703027 hasConcept C2778738651 @default.
• W2023703027 hasConcept C2780352252 @default.
• W2023703027 hasConcept C3018481051 @default.
• W2023703027 hasConcept C48856860 @default.
• W2023703027 hasConcept C71315377 @default.
• W2023703027 hasConcept C71924100 @default.
• W2023703027 hasConcept C77805123 @default.
• W2023703027 hasConceptScore W2023703027C115816405 @default.
• W2023703027 hasConceptScore W2023703027C126322002 @default.
• W2023703027 hasConceptScore W2023703027C130093455 @default.
• W2023703027 hasConceptScore W2023703027C134018914 @default.
• W2023703027 hasConceptScore W2023703027C15744967 @default.
• W2023703027 hasConceptScore W2023703027C169760540 @default.
• W2023703027 hasConceptScore W2023703027C187288502 @default.
• W2023703027 hasConceptScore W2023703027C2778555786 @default.
• W2023703027 hasConceptScore W2023703027C2778738651 @default.
• W2023703027 hasConceptScore W2023703027C2780352252 @default.
• W2023703027 hasConceptScore W2023703027C3018481051 @default.
• W2023703027 hasConceptScore W2023703027C48856860 @default.
• W2023703027 hasConceptScore W2023703027C71315377 @default.
• W2023703027 hasConceptScore W2023703027C71924100 @default.
• W2023703027 hasConceptScore W2023703027C77805123 @default.
• W2023703027 hasIssue "24" @default.
• W2023703027 hasLocation W20237030271 @default.
• W2023703027 hasLocation W20237030272 @default.
• W2023703027 hasLocation W20237030273 @default.

• next