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- W2023705041 abstract "Objective This study is a retrospective analysis of stage IB–IIB cervical carcinoma patients who had received postoperative radiotherapy (PORT). Methods Eight hundred patients with stage IB–IIB cervical carcinomas who received PORT after radical hysterectomy and bilateral pelvic lymph node dissection (PLND) between February 1979 and March 2000 were analyzed. Results The median follow-up duration was 100 months. The 5-year overall survival (OS) and disease-free survival (DFS) rates were 88% and 81%, respectively. One hundred forty-six patients (18%) failed, and 103 of these had distant metastases. Multivariate analysis revealed that pelvic lymph node (LN) metastasis significantly compromised OS, DFS, pelvic failure-free survival (PFFS), and distant failure-free survival (DFFS) (P < 0.05). Patients with age <50 years, deep stromal invasion (DSI), and lymphovascular space invasion (LVSI) were significantly associated with a higher risk of distant metastasis after PORT. The incidences of late rectal, urinary, and small bowel complications of grade 3 or higher were 1.6%, 1.4%, and 1.0%, respectively. Conclusions PORT achieved good OS and DFS in the patients with risk factors after radical hysterectomy for stage IB–IIB cervical carcinomas. Distant metastasis was the major pattern of treatment failure after PORT. Effective systemic chemotherapy might be a breakthrough in improving the outcome of PORT in patients with cervical carcinomas." @default.
- W2023705041 created "2016-06-24" @default.
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- W2023705041 date "2005-02-01" @default.
- W2023705041 modified "2023-10-16" @default.
- W2023705041 title "Post-hysterectomy radiotherapy in FIGO stage IB–IIB uterine cervical carcinoma" @default.
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- W2023705041 doi "https://doi.org/10.1016/j.ygyno.2004.10.025" @default.
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