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• W2023705303 abstract "<i>Background/Aims:</i> Constitutional delay of growth and puberty (CDGP) with short stature is one of the most common problems in pediatrics. We compared the effects of letrozole with that of oxandrolone on predicted adult height (PAH), puberty, bone mineral density, serum insulin-like growth factor 1 (IGF-1) and blood lipoproteins. <i>Methods:</i> In a prospective, double-blind, randomized, placebo-controlled clinical trial, 91 CDGP boys (12.6–14.6 years old) with predicted short stature were treated with letrozole (2.5 mg/day), oxandrolone (2.5 mg/day), or placebo, at the outpatient pediatric endocrine clinic of Mofid Children’s Hospital in Tehran for 2 years. <i>Results:</i> Letrozole differed from oxandrolone and placebo in significantly increasing PAH (p < 0.05), and slightly but significantly decreasing HDL-cholesterol. Oxandrolone, and to a lesser degree letrozole, significantly increased the height standard deviation score and bone age compared to placebo. <i>Conclusion:</i> This first randomized controlled clinical trial in CDGD teenage boys with predicted short stature shows that letrozole increases PAH more than oxandrolone and advances pubertal stage and bone mineralization less." @default.
• W2023705303 created "2016-06-24" @default.
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• W2023705303 date "2010-01-01" @default.
• W2023705303 modified "2023-10-04" @default.
• W2023705303 title "A Double-Blind, Placebo-Controlled Comparison of Letrozole to Oxandrolone Effects upon Growth and Puberty of Children with Constitutional Delay of Puberty and Idiopathic Short Stature" @default.
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• W2023705303 doi "https://doi.org/10.1159/000315482" @default.
• W2023705303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20628237" @default.
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