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• W2023705353 abstract "A dysfunctional glutamatergic system has been implicated in the pathophysiology of schizophrenia. The group III metabotropic glutamate receptor (mGluR) types 7 and 8 presynaptically inhibit glutamate release, thereby modulating glutamatergic transmission in the brain. We conducted association studies to investigate the novel Tyr433Phe (mGluR7) variant and the 2846-C/T (mGluR8) polymorphism in schizophrenia. Both variants, present at high frequencies, failed to demonstrate any significant association with schizophrenia (mGluR7 [Tyr433Phe] allele: P=0.33; genotype: P=0.63; mGluR8 [2846-C/T] allele: P=0.72; genotype: P=0.63)." @default.
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• W2023705353 date "2001-01-01" @default.
• W2023705353 modified "2023-10-13" @default.
• W2023705353 title "Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia" @default.
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• W2023705353 doi "https://doi.org/10.1016/s0920-9964(99)00235-2" @default.
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