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- W2023705862 abstract "ICI 89,406, a new cardioselective beta-adrenoceptor antagonist possessing marked intrinsic sympathomimetic activity, was administered (0.04 mg/kg, i.v.) to 10 patients with stable, uncomplicated, exercise-induced angina pectoris and angiographically proven coronary artery disease. The drug resulted in a significant reduction in heart rate (from 125 ± 5 to 110 ± 4/min, p < 0.001), mean systemic arterial pressure (from 147 ± 4 to 137 ± 3 mm Hg, p < 0.01), and electrocardiographic ST-segment depression (from 1.9 ± 0.5 to 0.8 ± 0.3 mm, p < 0.01) without any change in pulmonary arterial or wedge pressure during submaximal supine leg exercise on a bicycle ergometer. These changes were accompanied by a reduction of cardiac output in 6/10 patients and of the duration of pain in 8/10 patients. At rest, all the hemodynamic parameters remained essentially unchanged in comparison with the control study. These studies indicate that ICI 89,406 produces effective beta-adrenoceptor blockade during exercise in patients with angina pectoris. The partial agonist activity of the drug may be responsible for the minimal circulatory response at rest." @default.
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- W2023705862 date "1980-07-01" @default.
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- W2023705862 title "Clinical, Electrocardiographic, and Hemodynamic Effects of ICI 89,406, a New Cardioselective Beta-Adrenoceptor Antagonist with Intrinsic Sympathomimetic Activity, in Patients with Angina Pectoris" @default.
- W2023705862 doi "https://doi.org/10.1097/00005344-198007000-00010" @default.
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