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• W2023706461 abstract "The Cell division cycle 7 (Cdc7) protein kinase is essential for DNA replication and maintenance of genome stability. We systematically explored thiazole-based compounds as inhibitors of Cdc7 kinase activity in cancer cells. Our studies resulted in the identification of a potent, selective Cdc7 inhibitor that decreased phosphorylation of the direct substrate MCM2 in vitro and in vivo, and inhibited DNA synthesis and cell viability in vitro." @default.
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• W2023706461 date "2014-06-01" @default.
• W2023706461 modified "2023-10-16" @default.
• W2023706461 title "Synthesis and structure–activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors" @default.
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• W2023706461 doi "https://doi.org/10.1016/j.ejmech.2014.04.013" @default.
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