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• W2023707674 abstract "GDF-8 is recognised as an inhibitor of muscle cell growth and differentiation. Although initially thought to be restricted to muscle cells it is now accepted that GDF-8 expression has a broader tissue distribution. We demonstrate GDF-8 expression in the mouse mammary gland, which is predominantly associated with epithelial cells and displays an inverse correlation to the differentiated state of the gland. Specifically, the highest GDF-8 mRNA levels correlate with periods of maximal ductal growth, diminish as pregnancy progressed and are down-regulated to minimal levels by the onset of lactation as the epithelium differentiates. A similar profile is observed for both GDF-8 protein processing and reflects Smad2/3 phosphorylation profile. However, in contrast to muscle cells, GDF-8 neither reduces proliferation nor induces p21 expression levels in mammary epithelial cells. These data implicate a role for GDF-8 in mammary epithelial cell differentiation and demonstrate that GDF-8 has cell-type specific activities. Mol. Reprod. Dev. 75: 1783–1788, 2008. © 2008 Wiley-Liss, Inc." @default.
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• W2023707674 date "2008-12-01" @default.
• W2023707674 modified "2023-10-15" @default.
• W2023707674 title "Mammary gland differentiation inversely correlates with GDF-8 expression" @default.
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• W2023707674 doi "https://doi.org/10.1002/mrd.20918" @default.
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