Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023708189> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2023708189 endingPage "263" @default.
- W2023708189 startingPage "257" @default.
- W2023708189 abstract "Purpose: To evaluate the ocular pharmacokinetics and availability of baicalein following topical application. Methods: Hydroxypropyl beta-cyclodextrin (HP-β -CD) was used to formulate an aqueous eye drop to improve aqueous solubility of baicalein. A single dose of either baicalein suspension (1%) (Bai-SP) or baicalein (1%)/HP-β -CD (10%) solution (Bai-CD) was topically applied to rabbits. Aqueous humor and cornea were collected after 5, 10, 20, 30, 45, 60, 90, and 120 min. Baicalein concentrations were determined by high-performance liquid chromatography (HPLC) after extraction. Results: After topically applying Bai-CD, the baicalein concentrations in aqueous humor were significantly increased at 20–120 min except at 90 min compared with those of Bai-SP (p < 0.05). The highest levels of baicalein in aqueous humor (Cmax, 4.11 ± 0.75 μ g/ml) were obtained after 30 min application of Bai-CD, 3.6 times greater than that corresponding to the Bai-SP at 20 min. The Bai-CD produced an over 2.1-fold bioavailability (AUC0−120, area under the concentration time curve between 0 and 120 min) increase in aqueous humor compared to the Bai-SP. Peak baicalein concentration in cornea (56.53 ± 17.02 μ g/g) was achieved within 5 min after topical application of Bai-CD and 4.5 times higher than that of Bai-SP at the same timepoint. The baicalein levels in corneas obtained after application of Bai-CD were all much higher than those obtained by Bai-SP (p < 0.01), whereas the drug levels became undetectable 30 min after topical application of Bai-SP. Conclusion: Bai-CD formulation is superior to Bai-SP for increasing ocular bioavailability." @default.
- W2023708189 created "2016-06-24" @default.
- W2023708189 creator A5016722530 @default.
- W2023708189 creator A5056091982 @default.
- W2023708189 creator A5063180478 @default.
- W2023708189 creator A5066716873 @default.
- W2023708189 date "2009-01-01" @default.
- W2023708189 modified "2023-09-24" @default.
- W2023708189 title "Ocular Pharmacokinetics and Availability of Topically Applied Baicalein in Rabbits" @default.
- W2023708189 cites W1964229819 @default.
- W2023708189 cites W1970311735 @default.
- W2023708189 cites W1974400694 @default.
- W2023708189 cites W1977633303 @default.
- W2023708189 cites W1985907404 @default.
- W2023708189 cites W1992834995 @default.
- W2023708189 cites W1994292044 @default.
- W2023708189 cites W1994438083 @default.
- W2023708189 cites W2009918397 @default.
- W2023708189 cites W2018625099 @default.
- W2023708189 cites W2023758257 @default.
- W2023708189 cites W2026858652 @default.
- W2023708189 cites W2071213207 @default.
- W2023708189 cites W2073394985 @default.
- W2023708189 cites W2081691872 @default.
- W2023708189 cites W307898453 @default.
- W2023708189 cites W3142856279 @default.
- W2023708189 doi "https://doi.org/10.1080/02713680902725962" @default.
- W2023708189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19373573" @default.
- W2023708189 hasPublicationYear "2009" @default.
- W2023708189 type Work @default.
- W2023708189 sameAs 2023708189 @default.
- W2023708189 citedByCount "9" @default.
- W2023708189 countsByYear W20237081892013 @default.
- W2023708189 countsByYear W20237081892014 @default.
- W2023708189 countsByYear W20237081892019 @default.
- W2023708189 countsByYear W20237081892022 @default.
- W2023708189 crossrefType "journal-article" @default.
- W2023708189 hasAuthorship W2023708189A5016722530 @default.
- W2023708189 hasAuthorship W2023708189A5056091982 @default.
- W2023708189 hasAuthorship W2023708189A5063180478 @default.
- W2023708189 hasAuthorship W2023708189A5066716873 @default.
- W2023708189 hasConcept C112705442 @default.
- W2023708189 hasConcept C118487528 @default.
- W2023708189 hasConcept C147789679 @default.
- W2023708189 hasConcept C179998833 @default.
- W2023708189 hasConcept C181389837 @default.
- W2023708189 hasConcept C184651966 @default.
- W2023708189 hasConcept C185592680 @default.
- W2023708189 hasConcept C22979827 @default.
- W2023708189 hasConcept C2776882836 @default.
- W2023708189 hasConcept C2781466915 @default.
- W2023708189 hasConcept C2993390227 @default.
- W2023708189 hasConcept C43617362 @default.
- W2023708189 hasConcept C71924100 @default.
- W2023708189 hasConcept C98274493 @default.
- W2023708189 hasConceptScore W2023708189C112705442 @default.
- W2023708189 hasConceptScore W2023708189C118487528 @default.
- W2023708189 hasConceptScore W2023708189C147789679 @default.
- W2023708189 hasConceptScore W2023708189C179998833 @default.
- W2023708189 hasConceptScore W2023708189C181389837 @default.
- W2023708189 hasConceptScore W2023708189C184651966 @default.
- W2023708189 hasConceptScore W2023708189C185592680 @default.
- W2023708189 hasConceptScore W2023708189C22979827 @default.
- W2023708189 hasConceptScore W2023708189C2776882836 @default.
- W2023708189 hasConceptScore W2023708189C2781466915 @default.
- W2023708189 hasConceptScore W2023708189C2993390227 @default.
- W2023708189 hasConceptScore W2023708189C43617362 @default.
- W2023708189 hasConceptScore W2023708189C71924100 @default.
- W2023708189 hasConceptScore W2023708189C98274493 @default.
- W2023708189 hasIssue "4" @default.
- W2023708189 hasLocation W20237081891 @default.
- W2023708189 hasLocation W20237081892 @default.
- W2023708189 hasOpenAccess W2023708189 @default.
- W2023708189 hasPrimaryLocation W20237081891 @default.
- W2023708189 hasRelatedWork W1969574919 @default.
- W2023708189 hasRelatedWork W2068318921 @default.
- W2023708189 hasRelatedWork W2074399051 @default.
- W2023708189 hasRelatedWork W2080955156 @default.
- W2023708189 hasRelatedWork W2214737300 @default.
- W2023708189 hasRelatedWork W2297740383 @default.
- W2023708189 hasRelatedWork W2369983184 @default.
- W2023708189 hasRelatedWork W2373237830 @default.
- W2023708189 hasRelatedWork W2390225596 @default.
- W2023708189 hasRelatedWork W2418409895 @default.
- W2023708189 hasVolume "34" @default.
- W2023708189 isParatext "false" @default.
- W2023708189 isRetracted "false" @default.
- W2023708189 magId "2023708189" @default.
- W2023708189 workType "article" @default.