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- W2023708482 abstract "Clinical, biochemical and genetic evidence now indicates that schizophrenia is a disorder of membrane phospholipid metabolism associated with increased loss of highly polyunsaturated fatty acids from membranes owing to enhanced activity of a phospholipase A2. This changes the properties of membranes throughout the body and is responsible for such physical abnormalities as reduced vasodilator responses to niacin and histamine and altered immunological functions. A modest membrane abnormality is likely to produce its most serious consequences in the brain, which requires the co-ordinated sequential and parallel activities of millions of neurons. The concept leads to testable proposals for relatively simple and safe treatment modalities." @default.
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- W2023708482 date "1996-08-01" @default.
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- W2023708482 title "Schizophrenia as a membrane lipid disorder which is expressed throughout the body" @default.
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- W2023708482 doi "https://doi.org/10.1016/s0952-3278(96)90138-6" @default.
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