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• W2023708667 abstract "To determine the graft-versus-leukemia effect after hematopoietic stem cell transplantation (HSCT), we studied 199 patients with acute lymphoblastic leukemia who underwent transplantation at Huddinge University Hospital between 1981 and 2001. Seventy-four patients were in first complete remission (CR1), and 125 were in later stages of the disease. Most patients had an HLA-identical sibling donor. Conditioning consisted mainly of total body irradiation and cyclophosphamide, and graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and methotrexate. Acute GVHD developed in 143 patients and chronic GVHD in 67. The 5-year probability of relapse and relapse-free survival (RFS) were 32% and 49%, respectively, in patients in CR1, as compared with 53% and 33% in those with more advanced disease. In the multivariate risk factor analysis of relapse, we found that the absence of chronic GVHD (P < .001), absence of herpes simplex virus infection after HSCT (P = .003), combination prophylaxis with methotrexate and cyclosporine (P = .01), and >6 weeks from the diagnosis to CR (P = .025) were independent risk factors for relapse after HSCT. Factors associated with a better relapse-free survival were chronic GVHD (P < .001), ABO blood group mismatch (P = .006), younger patient age (P = .01), and an HLA-matched donor (P = .01). The association between herpes simplex virus infection and a low frequency of relapse is a new observation and may indicate that viral antigens play a role in the induction of an antileukemic effect." @default.
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• W2023708667 date "2004-03-01" @default.
• W2023708667 modified "2023-10-11" @default.
• W2023708667 title "Graft-versus-host disease is associated with a lower relapse incidence after hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia" @default.
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• W2023708667 doi "https://doi.org/10.1016/j.bbmt.2003.11.002" @default.
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