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• W2023711089 abstract "Three polyhydroxy-2-phenylnaphthalenes (1-3) and the oxy analogue of tetrahydroxypavinan (4) were prepared and evaluated for their antioxidant properties (inhibition of diphenylpycrylhydrazyl radical (DPPH), reduction of iron (III) ion) and inhibition of 5-lipoxygenase (5-LO) activity. Their three-dimensional structures were established on the basis of spectroscopic data and semiempirical calculations. Compounds 1 and 2 were found as potent 5-LO inhibitors as nordihydroguaiaretic acid (NDGA), whereas 4 is 2.5 times less potent than NDGA. The reliability of the 3-D structures with the 5-LO inhibition properties is discussed. Their antioxidant properties show that tested compounds are expected to act as redox inhibitors." @default.
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• W2023711089 date "2001-02-01" @default.
• W2023711089 modified "2023-10-06" @default.
• W2023711089 title "New Bis-catechols 5-lipoxygenase inhibitors" @default.
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• W2023711089 doi "https://doi.org/10.1016/s0968-0896(00)00258-3" @default.
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