FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023713532> ?p ?o ?g. }

• W2023713532 endingPage "262" @default.
• W2023713532 startingPage "253" @default.
• W2023713532 abstract "Reduced IGF-I is associated with low bone mass in humans and mice. C3H/He/J (C3H) mice have higher skeletal IGF-I and greater bone mass than C57BL/6J (B6). We hypothesized that strain-related genotypic differences in Igf1 affected skeletal function. The Igf1 coding region is nonpolymorphic, but its 3′ untranslated region (UTR) is polymorphic between C3H and B6. Luciferase-Igf1 3′ UTR reporter constructs showed that these polymorphic regions did not affect UTR function. IGF-I splice variants give rise to a common mature IGF-I peptide, but different E peptides. We identified two splice products, exon 4+6 (Ea) and exon 4+5+6 (Eb, mechano-growth factor) and found that their abundance was unchanged during osteoblastic differentiation. The Igf1 3′ UTR encoded by exon 6 contains alternative polyadenylation sites. Proximal site use produces a short 3′ UTR of approximately 195 bases, whereas distal site usage results in an approximately 6300-base UTR. Although Igf1 mRNA levels did not change during osteoblastic differentiation, distal polyadenylation site usage was increased in B6 cells but not in C3H. The resulting long Igf1 RNA isoform is less stable and has decreased translation efficiency, which may be one mechanism contributing to decreased IGF-I in B6 vs. C3H mice. Although the long UTR contains a conserved [GU]18 repeat, which is a positive regulator of UTR activity, it is also targeted by negative regulators, miR-29 and miR-365. These microRNAs are increased in B6 and C3H cells during osteoblastic differentiation. Differential expression of the long Igf1 3′ UTR isoform may be a possible mechanism for enhanced IGF-I regulation in B6 vs. C3H mice." @default.
• W2023713532 created "2016-06-24" @default.
• W2023713532 creator A5047044979 @default.
• W2023713532 creator A5050692693 @default.
• W2023713532 creator A5050798361 @default.
• W2023713532 creator A5069716219 @default.
• W2023713532 creator A5082580285 @default.
• W2023713532 date "2013-01-01" @default.
• W2023713532 modified "2023-10-18" @default.
• W2023713532 title "IGF-I 3′ Untranslated Region: Strain-Specific Polymorphisms and Motifs Regulating IGF-I in Osteoblasts" @default.
• W2023713532 cites W1563316806 @default.
• W2023713532 cites W1595565889 @default.
• W2023713532 cites W1964727443 @default.
• W2023713532 cites W1966936238 @default.
• W2023713532 cites W1971158461 @default.
• W2023713532 cites W1978883675 @default.
• W2023713532 cites W1996024484 @default.
• W2023713532 cites W1997196734 @default.
• W2023713532 cites W2003889314 @default.
• W2023713532 cites W2009667193 @default.
• W2023713532 cites W2010427162 @default.
• W2023713532 cites W2011920499 @default.
• W2023713532 cites W2017435031 @default.
• W2023713532 cites W2020433571 @default.
• W2023713532 cites W2023034939 @default.
• W2023713532 cites W2024036230 @default.
• W2023713532 cites W2028419771 @default.
• W2023713532 cites W2029777603 @default.
• W2023713532 cites W2033645202 @default.
• W2023713532 cites W2038854668 @default.
• W2023713532 cites W2047008025 @default.
• W2023713532 cites W2053629242 @default.
• W2023713532 cites W2058484411 @default.
• W2023713532 cites W2058840520 @default.
• W2023713532 cites W2061443977 @default.
• W2023713532 cites W2061780480 @default.
• W2023713532 cites W2071432376 @default.
• W2023713532 cites W2075262429 @default.
• W2023713532 cites W2087789109 @default.
• W2023713532 cites W2089125941 @default.
• W2023713532 cites W2092740654 @default.
• W2023713532 cites W2093281361 @default.
• W2023713532 cites W2093663819 @default.
• W2023713532 cites W2093963603 @default.
• W2023713532 cites W2095722048 @default.
• W2023713532 cites W2099382928 @default.
• W2023713532 cites W2103890520 @default.
• W2023713532 cites W2105493915 @default.
• W2023713532 cites W2105613536 @default.
• W2023713532 cites W2111265707 @default.
• W2023713532 cites W2118031210 @default.
• W2023713532 cites W2125965105 @default.
• W2023713532 cites W2126823300 @default.
• W2023713532 cites W2128254747 @default.
• W2023713532 cites W2133876293 @default.
• W2023713532 cites W2143297340 @default.
• W2023713532 cites W2143335836 @default.
• W2023713532 cites W2145349151 @default.
• W2023713532 cites W2148583445 @default.
• W2023713532 cites W2148676055 @default.
• W2023713532 cites W2151562469 @default.
• W2023713532 cites W2153401206 @default.
• W2023713532 cites W2155290141 @default.
• W2023713532 cites W2155804510 @default.
• W2023713532 cites W2158964360 @default.
• W2023713532 cites W2162759373 @default.
• W2023713532 cites W2163227336 @default.
• W2023713532 cites W2163416924 @default.
• W2023713532 cites W2167827709 @default.
• W2023713532 cites W2168552645 @default.
• W2023713532 doi "https://doi.org/10.1210/en.2012-1476" @default.
• W2023713532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3529377" @default.
• W2023713532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23183171" @default.
• W2023713532 hasPublicationYear "2013" @default.
• W2023713532 type Work @default.
• W2023713532 sameAs 2023713532 @default.
• W2023713532 citedByCount "20" @default.
• W2023713532 countsByYear W20237135322013 @default.
• W2023713532 countsByYear W20237135322014 @default.
• W2023713532 countsByYear W20237135322016 @default.
• W2023713532 countsByYear W20237135322017 @default.
• W2023713532 countsByYear W20237135322018 @default.
• W2023713532 countsByYear W20237135322019 @default.
• W2023713532 countsByYear W20237135322020 @default.
• W2023713532 countsByYear W20237135322021 @default.
• W2023713532 crossrefType "journal-article" @default.
• W2023713532 hasAuthorship W2023713532A5047044979 @default.
• W2023713532 hasAuthorship W2023713532A5050692693 @default.
• W2023713532 hasAuthorship W2023713532A5050798361 @default.
• W2023713532 hasAuthorship W2023713532A5069716219 @default.
• W2023713532 hasAuthorship W2023713532A5082580285 @default.
• W2023713532 hasBestOaLocation W20237135321 @default.
• W2023713532 hasConcept C104317684 @default.
• W2023713532 hasConcept C105580179 @default.
• W2023713532 hasConcept C134018914 @default.
• W2023713532 hasConcept C142575336 @default.
• W2023713532 hasConcept C145059251 @default.
• W2023713532 hasConcept C153911025 @default.

• next