Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023720146> ?p ?o ?g. }
- W2023720146 endingPage "1793" @default.
- W2023720146 startingPage "1782" @default.
- W2023720146 abstract "The hematopoietic system provides an attractive model for studying growth factor-controlled expansion and differentiation of cells in relation to receptor routing and its consequences for signal transduction. Suppressor of cytokine signaling (SOCS) proteins regulate receptor signaling partly via their ubiquitin ligase (E3)-recruiting SOCS box domain. Whether SOCS proteins affect signaling through modulating intracellular trafficking of receptors is unknown. Here, we show that a juxtamembrane lysine residue (K632) of the granulocyte colony-stimulating factor receptor (G-CSFR) plays a key role in receptor routing and demonstrate that the effects of SOCS3 on G-CSF signaling to a major extent depend on this lysine. Mutation of K632 causes accumulation of G-CSFR in early endosomes and leads to sustained activation of signal transducer and activator of transcription 5 and ERK, but not protein kinase B. Myeloid progenitors expressing G-CSFR mutants lacking K632 show a perturbed proliferation/differentiation balance in response to G-CSF. This is the first demonstration of SOCS-mediated ubiquitination and routing of a cytokine receptor and its impact on maintaining an appropriate signaling output." @default.
- W2023720146 created "2016-06-24" @default.
- W2023720146 creator A5003114996 @default.
- W2023720146 creator A5007739879 @default.
- W2023720146 creator A5019814633 @default.
- W2023720146 creator A5031532026 @default.
- W2023720146 creator A5057670996 @default.
- W2023720146 creator A5068990971 @default.
- W2023720146 date "2007-03-15" @default.
- W2023720146 modified "2023-10-10" @default.
- W2023720146 title "Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor" @default.
- W2023720146 cites W1501089098 @default.
- W2023720146 cites W1519421161 @default.
- W2023720146 cites W1577478964 @default.
- W2023720146 cites W1631627654 @default.
- W2023720146 cites W1824636958 @default.
- W2023720146 cites W1855620956 @default.
- W2023720146 cites W1965572772 @default.
- W2023720146 cites W1978816877 @default.
- W2023720146 cites W1979810396 @default.
- W2023720146 cites W1990259051 @default.
- W2023720146 cites W1997386124 @default.
- W2023720146 cites W1999236739 @default.
- W2023720146 cites W2005722151 @default.
- W2023720146 cites W2016324935 @default.
- W2023720146 cites W2016409733 @default.
- W2023720146 cites W2025236720 @default.
- W2023720146 cites W2026055716 @default.
- W2023720146 cites W2034947351 @default.
- W2023720146 cites W2035009997 @default.
- W2023720146 cites W2041355362 @default.
- W2023720146 cites W2048221101 @default.
- W2023720146 cites W2051338141 @default.
- W2023720146 cites W2051521460 @default.
- W2023720146 cites W2055786440 @default.
- W2023720146 cites W2061268223 @default.
- W2023720146 cites W2068968795 @default.
- W2023720146 cites W2086971705 @default.
- W2023720146 cites W2089127654 @default.
- W2023720146 cites W2096498130 @default.
- W2023720146 cites W2097645314 @default.
- W2023720146 cites W2108438806 @default.
- W2023720146 cites W2116552695 @default.
- W2023720146 cites W2121636916 @default.
- W2023720146 cites W2131491926 @default.
- W2023720146 cites W2134219637 @default.
- W2023720146 cites W2134391743 @default.
- W2023720146 cites W2136530061 @default.
- W2023720146 cites W2144958713 @default.
- W2023720146 cites W2145996190 @default.
- W2023720146 cites W2150316152 @default.
- W2023720146 cites W2155854462 @default.
- W2023720146 cites W2158519848 @default.
- W2023720146 cites W2160822037 @default.
- W2023720146 cites W2207563437 @default.
- W2023720146 cites W2268635172 @default.
- W2023720146 cites W2313319084 @default.
- W2023720146 cites W2399886424 @default.
- W2023720146 cites W2411955162 @default.
- W2023720146 cites W297316515 @default.
- W2023720146 doi "https://doi.org/10.1038/sj.emboj.7601640" @default.
- W2023720146 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1888671" @default.
- W2023720146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17363902" @default.
- W2023720146 hasPublicationYear "2007" @default.
- W2023720146 type Work @default.
- W2023720146 sameAs 2023720146 @default.
- W2023720146 citedByCount "82" @default.
- W2023720146 countsByYear W20237201462012 @default.
- W2023720146 countsByYear W20237201462013 @default.
- W2023720146 countsByYear W20237201462014 @default.
- W2023720146 countsByYear W20237201462015 @default.
- W2023720146 countsByYear W20237201462016 @default.
- W2023720146 countsByYear W20237201462017 @default.
- W2023720146 countsByYear W20237201462018 @default.
- W2023720146 countsByYear W20237201462019 @default.
- W2023720146 countsByYear W20237201462020 @default.
- W2023720146 countsByYear W20237201462021 @default.
- W2023720146 countsByYear W20237201462022 @default.
- W2023720146 countsByYear W20237201462023 @default.
- W2023720146 crossrefType "journal-article" @default.
- W2023720146 hasAuthorship W2023720146A5003114996 @default.
- W2023720146 hasAuthorship W2023720146A5007739879 @default.
- W2023720146 hasAuthorship W2023720146A5019814633 @default.
- W2023720146 hasAuthorship W2023720146A5031532026 @default.
- W2023720146 hasAuthorship W2023720146A5057670996 @default.
- W2023720146 hasAuthorship W2023720146A5068990971 @default.
- W2023720146 hasBestOaLocation W20237201461 @default.
- W2023720146 hasConcept C104317684 @default.
- W2023720146 hasConcept C106363011 @default.
- W2023720146 hasConcept C109159458 @default.
- W2023720146 hasConcept C121608353 @default.
- W2023720146 hasConcept C126042315 @default.
- W2023720146 hasConcept C134459356 @default.
- W2023720146 hasConcept C14077384 @default.
- W2023720146 hasConcept C148968398 @default.
- W2023720146 hasConcept C14942488 @default.
- W2023720146 hasConcept C179185449 @default.
- W2023720146 hasConcept C25602115 @default.